OsteoArticular Sepsis in Intensive Care unitS

Last updated: July 9, 2025
Sponsor: Assistance Publique - Hôpitaux de Paris
Overall Status: Active - Recruiting

Phase

N/A

Condition

Soft Tissue Infections

Osteomyelitis

Treatment

N/A

Clinical Study ID

NCT06627842
APHP241174
  • Ages > 18
  • All Genders

Study Summary

This is an ambispective observational study of patients admitted to intensive care with a diagnosis of joint prosthesis infection (mainly knee and hip prostheses). The main objective of the study is to describe the profile, care trajectories during the stay (before or after surgery) and prognosis of patients admitted to critical care with such an infection. We also aim to compare prognosis between different groups of patients sharing the same profile and care trajectory, and to assess independent risk factors associated with 2-year mortality among the study population. Finally, we will describe the microbiological and resistance profile of severe osteoarticular device infections requiring critical care admission in France.

This is a descriptive and analytical observational study open to all French public and private hospitals.

Patient data will be retrieved prospectively from patient source files. Only 2-year data (vital status, functional data) will be collected specifically for the study, by telephone contact with the patient or his or her support person.

Eligibility Criteria

Inclusion

Inclusion Criteria:

  • Patient at least 18 years old.

  • Hospitalization in critical care (intensive care unit or continuing care unit)between 2018 and 2022 of at least 48 hours, with prosthetic joint infection (hip,knee or shoulder prosthesis infection) as the main or associated diagnosis.

Exclusion

Exclusion Criteria:

  • Infection on osteosynthesis material

  • Infection on spinal equipment

  • Patient with several infected prostheses

  • Recurrence of infection on prosthesis with the same microorganism

  • Patient opposing data collection

  • Patient under legal protection.

  • Pregnant or breast-feeding patient.

  • Patient deprived of liberty.

Study Design

Total Participants: 150
Study Start date:
March 31, 2025
Estimated Completion Date:
July 31, 2025

Connect with a study center

  • Hôpital Lariboisière

    Paris, 75010
    France

    Active - Recruiting

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