Study to Evaluate Ultevursen in Subjects With Retinitis Pigmentosa (RP) Due to Mutations in Exon 13 of the USH2A Gene

Inclusion Criteria:

1. An adult (≥18 years) willing and able to provide informed consent for participationprior to performing any study related procedures OR A minor (8 to less than 18years) able to provide age-appropriate assent for study participation with a parentor legal guardian willing and able to provide written permission for the subject'sparticipation prior to performing any study related procedures.

2. Both eyes exhibit clinical presentation consistent with RP involving Usher syndrometype 2 or NSRP based on ophthalmic, audiologic, or vestibular examinations. Atscreening, the Investigator will make the clinical diagnosis of "Usher syndrome type 2a," defined as RP with congenital hearing loss, or "non-syndromic RP," defined asRP without congenital hearing loss.

3. A molecular diagnosis of biallelic disease causing variants (pathogenic or likelypathogenic) in the USH2A gene where at least one of the variants is located on exon

4. A historic genotyping report from a certified laboratory is acceptable withSponsor approval.

5. Clearly visible and measurable EZ width of ≥2.5 mm in both horizontal and verticalscans in both eyes as measured by SD-OCT and based on the assessment of the CRC.

6. BCVA ≥55 letters based on ETDRS (equivalent to 20/80 based on Snellen notation, orlogarithm of the minimum angle of resolution [logMAR] +0.6) in both eyes.

7. Impairment of VF as assessed by SP with a mean sensitivity greater than 4 decibels (dB) and less than 25 dB measured by a V4e target size in the TE.

8. Mean sensitivity greater than 2 dB as determined by MP in the TE.

9. Symmetry of baseline disease in both eyes, defined as the mean BCVA (based on ETDRS)of one eye within ≤10 letters of the mean BCVA of the other eye at screening. Ifthis is not present, the Investigator should discuss the case with the MedicalMonitor to decide whether it is appropriate for the subject to participate in thestudy. For purposes of determining symmetry, the mean BCVA for each eye will becalculated using all BCVA measures obtained during the screening period.

Exclusion Criteria:

1. Presence of additional non-exon 13 USH2A pathogenic or likely pathogenic variant onthe USH2A allele carrying the exon 13 mutation in subjects who have one exon 13disease causing variant and one non-exon 13 disease causing variant.

2. Presence of additional non-exon 13 USH2A pathogenic mutation(s) on both USH2Aalleles in subjects who have biallelic exon 13 mutations.

3. Presence of pathogenic or likely pathogenic variants in genes (other than the USH2Agene) which are known to be associated with other inherited retinal degenerativediseases or syndromes. Specifically, the presence of homozygous or compoundheterozygous known disease-causing mutations in other genes involved in recessiveretinal dystrophies, or the confirmed presence of a known single disease-causingvariant in genes involved in dominant, X-linked, or mitochondrial retinal dystrophygenes is exclusionary.

4. At screening, the EZ horizontal or vertical width are outside the field of theSD-OCT scan based on the assessment of the CRC.

5. Presence of any significant ocular or non-ocular disease/disorder (includingmedication and laboratory test abnormalities) which, in the opinion of theInvestigator and with concurrence of the Medical Monitor, may either put the subjectat risk because of participation in the study, may impact the subject's ability toparticipate in the study, or may interfere with assessment of efficacy and safety inthe study.

6. Presence of unstable concurrent cystoid macular edema (CME), or subject started on (or changed dose of) topical or systemic carbonic anhydrase inhibitor treatment inthe 3 months prior to enrollment. CME is allowed if stable for 3 months (with orwithout treatment). However, stable CME that disrupts the EZ width measurement, asdetermined by CRC, is an exclusion.

7. Receipt of any prior intraocular or periocular surgery or planned intraocularsurgery or procedure during the study. Subjects may be considered for inclusion ifthere are no clinically significant complications of surgery present and followingapproval by the Medical Monitor.

8. Receipt of any IVT injection prior to study entry. However, subjects who havereceived a prior IVT injection may be considered for inclusion following approval bythe Medical Monitor.