Key Longitudinal Associations With Risk and Glioblastoma Outcomes

Last updated: January 16, 2026
Sponsor: Duke University
Overall Status: Active - Recruiting

Phase

N/A

Condition

Astrocytoma

Gliomas

Treatment

N/A

Clinical Study ID

NCT06625684
Pro00114859
  • Ages > 18
  • All Genders

Study Summary

The goal of this observational study is to find out what factors affect the health and risks in adults with glioblastoma (GBM), a grade 4 brain cancer.

The main questions it aims to answer are:

  • How do genetic and immune system factors impact survival and quality of life in GBM patients?

  • What occupational and medical history factors are linked to the risk of getting GBM?

Participants will:

  • Fill out an online survey about their medical history and lifestyle.

Participants will have the chance to give a blood sample (from the outer arm) for genetic and immune system testing. Blood samples will be given using a home collection kit provided by the study team.

Eligibility Criteria

Inclusion

Inclusion Criteria:

  • At least 18 years old

  • Pathologically-confirmed diagnosis of glioblastoma multiforme (GBM) or grade 4 braintumor

  • Participant is accessible for follow-up (has a working email address)

  • Participant is willing and able to comply with the study requirements

Exclusion

Exclusion Criteria:

  • Those who cannot read either English or Spanish

  • Those who cannot view an online survey

Study Design

Total Participants: 200
Study Start date:
December 10, 2024
Estimated Completion Date:
December 10, 2029

Study Description

This observational study aims to investigate the various factors influencing outcomes and risks in adults diagnosed with glioblastoma (GBM). Glioblastoma is a highly aggressive and malignant brain tumor, and understanding the factors that affect patient outcomes is crucial for improving management strategies and patient care.

The study employs a case-only design where participants will be followed over time to observe how different factors affect their health outcomes. Participants will be selected based on their diagnosis of glioblastoma and will be included in the study regardless of current treatment status or disease stage.

Findings from this study are expected to provide valuable insights into the factors affecting glioblastoma outcomes and may contribute to the development of personalized treatment strategies and risk assessment tools for better management of the disease.

Connect with a study center

  • Duke University

    Durham, North Carolina 27710
    United States

    Site Not Available

  • Duke University

    Durham 4464368, North Carolina 4482348 27710
    United States

    Active - Recruiting

Map preview placeholder

Not the study for you?

Let us help you find the best match. Sign up as a volunteer and receive email notifications when clinical trials are posted in the medical category of interest to you.