Effects of Dexmedetomidine on Agitation in Critically Ill TBI Patients

Last updated: September 27, 2024
Sponsor: Centre Integre Universitaire de Sante et Services Sociaux du Nord de l'ile de Montreal
Overall Status: Active - Not Recruiting

Phase

2/3

Condition

Traumatic Brain Injury

Neurologic Disorders

Manic Disorders

Treatment

Placebo

Dexmedetomidine

Clinical Study ID

NCT06620393
MP-32-2024-2732
  • Ages > 18
  • All Genders

Study Summary

Agitation is a frequent complication following traumatic braing injury in patients admitted to the intensive care unit. This agitation frequently results in the liberal use of rescue drugs such as antipsychotics, sedatives and opiates, which in turn may delay rehabilitation, liberation from mechanical ventilation and emergence from posttraumatic amnesia. Dexmedetomidine may be a better agent given it's light sedative properties. The main objective is to assess the feasibility of conducting a multicenter randomized controlled trial of dexmedetomidine following TBI in the ICU.

Eligibility Criteria

Inclusion

Inclusion Criteria:

  1. Adults (≥18 years) admitted to ICU with a critically ill moderate or severe TBIpatients. Severity of TBI will be determined with the first Glasgow Coma Score (GCS). TBI patients with polytrauma and patients undergoing neurosurgicalinterventions will be eligible.

  2. Undergoing mechanically ventilation (of any duration) at the time of assessment.

  3. Anticipated ICU stay of 48 hours or more.

Exclusion

Exclusion Criteria:

  1. Patients at very high risk of short-term mortality (e.g., GCS of 3 without sedation,or unreactive pupils, or declared brain-dead when assessed for eligibility andpatients in whom there is a lack of commitment to ongoing life support

  2. Patients unable to communicate in English or French (interfering with posttraumaticamnesia assessments)

  3. Patients with cognitive impairment as per family evaluation

  4. Pregnant or breastfeeding

  5. Patients currently receiving DEX or clonidine

  6. Allergy, bradycardia or hypotension precluding use of dexmedetomidine as pertreating physician

Study Design

Total Participants: 72
Treatment Group(s): 2
Primary Treatment: Placebo
Phase: 2/3
Study Start date:
October 01, 2024
Estimated Completion Date:
December 01, 2026

Study Description

Following a traumatic brain injury, agitation is reported in 53-57% of patients in the intensive care unit. As it is associated with accidental removal of catheters, tubes and dressings as well as self-extubation, agitation poses a threat to patient safety. In addition, agitation can be accompanied by aggressive behaviors that pose a threat to clinician safety. This agitation frequently results in the liberal use of rescue drugs such as antipsychotics, sedatives and opiates, which in turn may delay rehabilitation, liberation from mechanical ventilation and emergence from posttraumatic amnesia. Dexmedetomidine is a highly selective alpha-2 adrenergic receptor agonist used for sedation and also has co-analgesic and withdrawal syndrome alleviating properties. Unlike other sedatives, patients remain easily roused when under dexmedetomidine, facilitating contact and removal from mechanical ventilation. In addition, dexmedetomidine does not induce respiratory depression in critically ill patients. The addition of dexmedetomidine may have the potential to reduce the incidence agitation while reducing the use of agitation rescue drugs such as antipsychotics, the use of physical restraints, as well as the time to cessation of mechanical ventilation and consequently, reduce the time to emergence for post-traumatic amnesia. Duration of posttraumatic amnesia is an important outcome as it is a predictor of cognitive and functional outcomes as well as community integration, psychosocial functioning and employment. The main objective is to assess the feasibility of conducting a multicenter randomized controlled trial of dexmedetomidine following TBI in the ICU. To evaluate the feasibility of conducting a large trial and to refine study procedures, a multicenter randomized double-blind placebo-controlled pilot study comparing dexmedetomidine to placebo will be conducted. The feasibility outcomes will include protocol adherence, trial recruitment and time-in-motion evaluation for study procedures. Clinical outcomes will include agitation, exposure to antipsychotics, time to emergence from post-traumatic amnesia, physical restraint use, ventilator days, and time to ICU and hospital discharge as well as ICU and hospital mortality.