Evaluation of the Anti-aging Efficacy of One Face Care Cosmetic Product

Inclusion Criteria:

• Written Informed Consent to participate in the study

• Willingness to actively participate in the study and to come to the scheduled visits

• Female and approximately 10% male (at least 4 male subjects)

• From 50 to 75 years of age

• Healthy skin in the test areas

• Visible wrinkles in the face (grade 3 to 6 according to SGS proderm scale)

For biopsy subpanel:

-Vaccination of tetanus within the last 10 years

Exclusion Criteria:

• Female subjects: Pregnancy or lactation

• Drug addicts, alcoholics

• AIDS, HIV-positive or infectious hepatitis

• Conditions which exclude a participation or might influence the testreaction/evaluation

• Participation or being in the waiting period after participation in cosmetic and/orpharmaceutical studies pertaining to the test area

• Active skin disease at the test area

• Documented allergies to face/eye care products

• Diabetes mellitus

• Cancer not being diagnosed as cured and requiring chemotherapy, irradiation and/orhormonal treatment within the last 2 years

• One of the following illnesses with reduced physical capability/fitness: asthma (symptom-free allergic asthma is not an exclusion criterion), hypertension (if notadjusted with medication), cardiovascular diseases

• Epilepsy

• Wounds, moles, tattoos, scars, irritated skin, excessive hair growth, freckles, etc.at the test area that could influence the investigation

• Regular use of tanning beds

• Any topical medication at the test area within the last 3 days prior to the start ofthe study

• Systemic therapy with immuno-suppressive drugs (e.g. corticosteroids) and/orantihistamines (e.g. antiallergics) and/or within the last 7 days prior to the startof the study

• Therapy with antibiotics within the last 2 weeks prior to the start of the study

• Past cosmetic surgery procedure in the test area (e.g. laser, facelift)

• Cosmetic surgery procedure in the test area, e.g. IPL (Intensed Pulsed Light),botox, chemical peel, dermabrasion within the last 2 years prior to the start of thestudy and/or throughout the entire course of the study

• Medical treatment for wrinkle reduction (e.g. peeling with vitamin A or fruit acids)on the face within the last 2 weeks prior to the start of the study

For biopsy subpanel:

• Regular medication with anti-coagulating drugs like Aspirin®, Macumar®, etc. (e.g.for thrombosis prophylaxis) within up to 15 days prior to the taking of the biopsies

• History of complications at wound healing (e.g. keloids, hypertrophic scars orcontracture scar)

• Known intolerance to local anaesthetics

• Known Sensitivity to any dressing systems