Study of SHR-8068 Combined With Adebrelimab and Bevacizumab Versus Sintilimab Combined With Bevacizumab for the Treatment of Advanced Hepatocellular Carcinoma

Inclusion Criteria:

1. Able and willing to provide a written informed consent

2. ≥ 18 years old, both male and female

3. Unresectable locally advanced or metastatic HCC confirmed byhistopathologically/cytologically

4. At least one measurable lesion based on RECIST v1.1 criteria

5. Barcelona clinic liver cancer: Stage B or C

6. No previous systemic antitumor therapy for HCC

7. ECOG PS of 0-1

8. Child-Pugh score of A or B7

9. Expected survival period ≥ 12 weeks

10. Adequate organ function

11. Blood pregnancy negative (women of childbearing age) and non-breastfeeding,effective contraception

Exclusion Criteria:

1. Hepatic cholangiocarcinoma, mixed hepatocellular carcinoma -cholangiocarcinoma,sarcomatoid hepatocellular carcinoma and fibrolamellar hepatocellular carcinoma

2. Patients with other malignancies currently or within the past 5 years

3. With known severe allergic reactions to any other monoclonal antibodies

4. Patients with known CNS metastasis or hepatic encephalopathy

5. Patients with liver tumor burden greater than 50% of total liver in volume orreceived liver transplants

6. Patients with symptomatic ascites or pleural effusion

7. Patients with hypertension which cannot be well controlled by antihypertensives

8. Uncontrolled cardiac diseases or symptoms

9. Known hereditary or acquired bleeding (e.g., coagulopathy) or a tendency to clot (e.g., hemophiliacs)

10. Major vascular disease occurred in the 6 months before randomization

11. Gastrointestinal perforation or gastrointestinal fistula within 6 months beforerandomization

12. Major surgery within 28 days before randomization or expected to require majorsurgery during the study period

13. Active infection, or fever of unknown cause ≥ 38.5℃ in the first 7 days ofrandomization, or WBC > 15×109/L at baseline

14. Known positive history of human immunodeficiency virus test or acquiredimmunodeficiency syndrome, known HBV infection, known HCV infection

15. Patients who received live vaccines within 28 days before randomization, or areexpected to be vaccinated during the treatment period

16. Patients with other potential factors that may affect the study results