PM8002 in Combination With Paclitaxel Compared With Chemotherapy as Second-line Treatment in Small Cell Lung Cancer

Inclusion Criteria:

1. Voluntary participation in this clinical study; full understanding of the study andvoluntary signing the informed consent form; willing to follow and abling tocomplete all trial procedures;

2. Age ≥18 years but ≤75 years;

3. Histologically or cytologically confirmed SCLC;

4. Advanced SCLC that has progressed or replased after first-line platinum-containingchemotherapy (extensive-stage patients must have received immune checkpointinhibitors);

5. Having adequate organ functions;

6. The Eastern Cancer Cooperative Group (ECOG) performance score of 0 or 1;

7. Life expectancy of 12 weeks or more;

8. Having at least one measurable tumor lesion according to RECIST v1.1;

Exclusion Criteria:

1. History of severe allergic disease, severe drug allergy or have known allergy to anycomponent of the study drugs;

2. Previous treatment with Paclitaxel or Topotecan or anti-vascular endothelial growthfactor (VEGF) target drugs;

3. Current presence of severe superior vena cava syndrome and spinal cord compression;

4. Adverse events resulting from prior anti-tumor therapies should be assessed andgraded according to the CTCAE 5.0 criteria, subjects whose AEs have not returned toGrade 1 or below;

5. Evidence of significant clotting disorder or other significant bleeding risk;

6. History of severe, uncontrollable, or active cardiovascular diseases within 6months;

7. Current presence of uncontrollable pleural, pericardial, and peritoneal effusions;

8. Human immunodeficiency virus (HIV) infection or known acquired immunodeficiencysyndrome;

9. History of allogeneic hematopoietic stem cell transplantation or allogeneic organtransplantation;

10. History of alcohol abuse, psychotropic substance abuse or drug abuse;

11. Pregnant or lactating women;

12. Other conditions considered unsuitable for this study by the investigator.