Effects Of Daily Taurine Intake For 6 Months On Biological Age and Body Metabolism Indicators As Well As Physical Fitness In 55-75-year-old Women And Men

Last updated: November 18, 2025
Sponsor: Technical University of Munich
Overall Status: Completed

Phase

N/A

Condition

Diabetes Prevention

Treatment

Placebo

4g of taurine daily

Clinical Study ID

NCT06613542
2024-253-S-CB
  • Ages 55-75
  • All Genders
  • Accepts Healthy Volunteers

Study Summary

The goal of this clinical trial is to investigate the effect of taking 4 grams of taurine by older adults on aging processes over a period of 6 months. It will also check for effects of taurine on participant's physical fitness, metabolic and cognitive functions. The main question it aims to answer is:

• Does a supplementation with 4 g of taurine daily over a period of 6 months slow down biological aging in humans? Researchers will compare supplementation with taurine to a placebo (a look-alike substance that contains no drug) to reliably determine whether taurine has an effect.

Participants will:

  • Take 4g of taurine or a placebo every day for 6 months

  • Visit the study site 4 times for checkups and tests: for a screening visit, at the beginning of the intervention, after 8 and 24 weeks

Eligibility Criteria

Inclusion

Inclusion Criteria:

  • women or men

  • Age 55 - 75

  • BMI 22 - 30 kg/m²

  • written consent

Exclusion

Exclusion Criteria:

  • Acute or chronic inflammation (e.g. flu infection)

  • Severe chronic illness (e.g., Type 1 or Type 2 diabetes mellitus, COPD, renalinsufficiency)

  • Myocardial infarction or stroke in the previous 6 months

  • Psychiatric disorder, including depression or dementia

  • Weight change of ≥ 5 kg in the last 6 months

Study Design

Total Participants: 90
Treatment Group(s): 2
Primary Treatment: Placebo
Phase:
Study Start date:
September 25, 2024
Estimated Completion Date:
November 13, 2025

Study Description

Measurements performed during study visits:

  • Biological age estimate via proteome analysis

  • Organ age estimates (proteomics)

  • DNA methylation

  • Inflammatory biomarkers (CRP, cytokines)

  • Metabolic variables: fasting blood glucose, insulin, HOMA-IR, HbA1c, lipids, BMI

  • Physical fitness (hand grip strength, leg extensor strength, PWC130)

  • Resting energy expenditure

  • Cognitive function via questionnaire

  • Quality of life

  • Heart rate variability

  • Physical activity, nutrition

Connect with a study center

  • Institute for Nutritional Medicine of Technical University of Munich

    Munich, 80992
    Germany

    Site Not Available

  • Institute for Nutritional Medicine of Technical University of Munich

    Munich 2867714, 80992
    Germany

    Site Not Available

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