Long-term Outcomes of Early-stage Nasopharyngeal Carcinoma Patients Treated with Radiotherapy Alone

Last updated: September 22, 2024
Sponsor: Taichung Veterans General Hospital
Overall Status: Active - Not Recruiting

Phase

N/A

Condition

Nasopharyngeal Cancer

Carcinoma

Cancer

Treatment

Radiology

Clinical Study ID

NCT06612697
CE23408A
  • Ages > 20
  • All Genders

Study Summary

Nasopharyngeal carcinoma (NPC) is a malignant tumor primarily originating in the nasopharynx, commonly found in populations in southern China, certain regions of Asia, and North Africa. The main treatment for NPC is primarily radiotherapy, with some patients receiving combined chemotherapy. Early-stage NPC patients can achieve adequate tumor control with radiation therapy alone. Various studies report that the 5-year survival rate for very early-stage NPC exceeds 90%. However, some stage I patients experience local recurrence or distant metastasis after treatment, indicating treatment failure. This study aims to retrospectively analyze the factors contributing to treatment failure and prognostic factors in this group of early-stage NPC patients.

Eligibility Criteria

Inclusion

Inclusion Criteria:

  • Diagnosed with nasopharyngeal carcinoma based on endoscopic pathological reports.

  • Included early-stage patients classified as cT1-2, cN0-1, M0.

  • Had baseline imaging (CT or MRI) prior to treatment.

  • Received definitive radiotherapy at our institution and had long-term follow-up withcomplete medical records.

Exclusion

Exclusion Criteria:

  • Excluded from the study are patients with local lymph node metastasis or distantmetastasis (cN ≥ 2, M = 1) as determined by imaging studies.

  • Patients who did not receive definitive radiotherapy at our institution or hadincomplete medical records during long-term follow-up are also excluded.

  • Patients diagnosed with any other primary cancer within five years prior to thediagnosis of nasopharyngeal carcinoma (excluding DCIS and skin cancer) are excludedfrom the study.

Study Design

Total Participants: 262
Treatment Group(s): 1
Primary Treatment: Radiology
Phase:
Study Start date:
October 02, 2023
Estimated Completion Date:
September 01, 2025

Connect with a study center

  • Taichung Veterans General Hospital

    Taichung,
    Taiwan

    Site Not Available

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