The Effect of Inulin in Irritable Bowel Syndrome

Last updated: September 20, 2024
Sponsor: Mardin Artuklu University
Overall Status: Completed

Phase

N/A

Condition

Depression

Functional Dyspepsia

Colic

Treatment

Prebiotic group

Maltodextrin (Placebo)

Clinical Study ID

NCT06610188
377
  • Ages 19-65
  • All Genders
  • Accepts Healthy Volunteers

Study Summary

Purpose: This study was conducted to evaluate the effect of inulin on bowel symptoms, depression and quality of life in individuals with constipation-dominant irritable bowel syndrome. Individuals (n=34) aged 21-63 years with constipation-dominant IBS were included in the study. Individuals were divided into two groups as prebiotic group [(n=17) (inulin/oligofructose 50/50 mixture of 4.6 g (Inulin=total 9.2 g) inulin/oligofructose 50/50 mixture twice a day)], and placebo [(n=17), (Maltodextrin=9.2 g)] group. The intervention period was 8 weeks and Bristol Stool Scale, IBS-Visual Analogue Scale, IBS-Symptom Severity Score Scale (IBS-SSS), IBS-Quality of Life Scale (IBS-QoL) and Beck Depression Scale were administered to the participants at the beginning, 1st month and 2nd month. SPSS software programme was used for statistical analysis of the data. It is thought that inulin supplementation may be effective in reducing symptom severity and frequency, improving bowel function (stool frequency, consistency and transit time) and quality of life, and thus may be beneficial in individuals with constipation-predominant IBS.

Eligibility Criteria

Inclusion

Inclusion Criteria:

  • the individuals were between 19-65 years of age

  • volunteer to participate in the study

  • Individuals diagnosed with IBS by a physician according to Rome IV criteria

Exclusion

Exclusion Criteria:

  • a history of gastrointestinal surgery (except appendectomy and cholecystectomy)

  • inflammatory bowel disease

  • lactose malabsorption

  • gastroenteritis

  • celiac disease

  • gastric

  • duodenal ulcer

  • metabolic diseases (cardiac, hepatic and renal diseases, diabetes, etc.)

  • history of malignancy

  • pregnancy and lactation

  • use of intestinal motility

  • antidepressant drugs

  • involuntary body weight loss of more than 5 kg in the last 3 months

  • use of dietary fibre supplements in the last 3 months

  • use of antibiotics in the last 3 months

  • use of prebiotic and probiotic supplements in the last 3 months.

Study Design

Total Participants: 34
Treatment Group(s): 2
Primary Treatment: Prebiotic group
Phase:
Study Start date:
November 03, 2021
Estimated Completion Date:
April 01, 2023

Study Description

In the treatment of IBS, a multimodel perspective that includes psychological support (cognitive behavioural therapy, stress management techniques, etc.) in addition to lifestyle changes (dietary changes, etc.) may be beneficial.

Connect with a study center

  • Mardin Artuklu University

    Mardin, 47200
    Turkey

    Site Not Available

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