Donafenib as Adjuvant Therapy Following Ablation for Recurrent HCC

Inclusion Criteria:

1. were aged 18-75 years;

2. had recurrent HCC (RHCC) diagnosed by imaging studies, the first or the second RHCC;

3. RHCC met the Milan criteria, namely single RHCC lesion less than 5 cm in diameter orno more than 3 tumors (each ≤3 cm in diameter);

4. the early RHCC (recurrent time <1 year)

5. patients were unwilling to undergo repeat hepatectomy or liver transplantation;

6. had well-preserved liver function, i.e., Child-Pugh class A or B, and prolongedprothrombin time≤5 s;

7. patients had an Eastern Cooperative Oncology Group performance status score ≤1.

8. Ability to understand the protocol and to agree to and sign a written informedconsent document.

Exclusion Criteria:

1. were under 18 years or over 75 years of age;

2. primary HCC;

3. recurrent HCC beyond Milan criteria;

4. RHCC with metastasis or macrovascular tumor thrombus