Transcranial Direct Current Stimulation on Post Stroke Depression

Last updated: March 19, 2025
Sponsor: Riphah International University
Overall Status: Active - Recruiting

Phase

N/A

Condition

Cerebral Ischemia

Stroke

Depression

Treatment

tDCS

Conventional treatment

Clinical Study ID

NCT06598670
REC02030 Jaweria Zaib Abbasi
  • Ages 25-75
  • All Genders

Study Summary

The aim of the research is to address the critical gap that limited number of RCTs are conducted on this topic. To further explore the efficacy of tDCs, large sample sizes, large follow up period and rigorously controlled randomized clinical trials are necessary. An optimum stimulation protocol is also needed on this study. Previous studies lack information regarding effects of this stimulation on depression, cognition, quality of life in relation to different severity levels of stroke.

Eligibility Criteria

Inclusion

Inclusion Criteria:

  • Stroke for more than 6 months Both gender with equal ratio on stroke severity basisDepression diagnosed by Psychiatrist Mild and moderate Depression at PHQ-9 NationalInstitutes of Health Stroke Scale (NIHSS) for severity level; Mild (1-4), Moderate (5-15), Moderate to Severe (16-20), Severe (21-42)

Exclusion

Exclusion Criteria:

  • Any medical condition like cardiac arrhythmias, uncontrolled hypertension.Individual with any pacemaker and metal implant in body. Patient with any otherneurological and psychiatric condition.

Study Design

Total Participants: 56
Treatment Group(s): 2
Primary Treatment: tDCS
Phase:
Study Start date:
October 25, 2024
Estimated Completion Date:
July 31, 2025

Study Description

Research studies revealed that PSD causes both cognitive and physical impairments to lower motivation, which hinders rehabilitation program participation and slows down executive functions. Due to depression, cognitive dysfunctions difficulty in executive, working memory and emotional deficits which declines quality of life (QoL). Thus, the combined effects of cognitive decline and PSD considerably more worsen stroke survivors' QoL with regard to psychological, environmental and physical well-being Evidence supports various techniques for minimizing PSD, restoring cognitive function, and enhancing QoL including mindfulness-based therapies, exercise therapy (aerobic and resistance trainings), progressive muscle relaxation exercises, cognitive behavioral therapy (CBT). Non-invasive brain stimulation (NIBS) include transcranial direct current stimulations (tDCS) demonstrated significant therapeutic outcomes in the PSD rehabilitation.

Connect with a study center

  • Pakistan Railway General Hospital

    Rawalpindi, Punjab 466000
    Pakistan

    Active - Recruiting

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