Chlorhexidine Lavage for Recurrent Urinary Tract Infection

Last updated: January 13, 2026
Sponsor: Oregon Health and Science University
Overall Status: Active - Not Recruiting

Phase

4

Condition

Urinary Tract Infections

Treatment

Chlorhexidine

Sterile Water

Clinical Study ID

NCT06598514
STUDY00027352
  • Ages 55-89
  • Female

Study Summary

A two-arm randomized control trial evaluating rates of urinary tract infection in post-menopausal women on vaginal estrogen with recurrent urinary tract infections.

Eligibility Criteria

Inclusion

Inclusion Criteria:

  • Post-menopausal female between age 55 and 89

  • No post-menopausal bleeding

  • Diagnosis of recurrent urinary tract infection (UTI) in the electronic health recordor as two culture proven UTIs in 6 months or three culture proven UTIs in 12 months

  • At least one UTI in the 6 months prior to entering the study

  • Asymptomatic for UTI symptoms at the time of enrollment.

  • On vaginal estrogen therapy for at least 6 weeks prior to enrollment

  • Ready access to email and internet

Exclusion

Exclusion Criteria:

  • Recent prophylactic antibiotic use (washout period of 4 weeks)

  • Neurogenic bladder

  • Diagnosis of urinary retention

  • Uncorrected Stage III-IV prolapse

  • Indwelling catheter or need for intermittent self-catheterization

  • History of complicated UTIs

  • History of interstitial cystitis or bladder pain syndrome

  • History of fecal incontinence/accidental bowel leakage

  • Greater than 14 bowel movements per week

  • Non-English speaking

  • Allergy to chlorhexidine gluconate

  • Inability to utilize vaginal estrogen therapy

  • Recent urogynecological or urologic surgery (<12 weeks)

Study Design

Total Participants: 136
Treatment Group(s): 2
Primary Treatment: Chlorhexidine
Phase: 4
Study Start date:
December 23, 2024
Estimated Completion Date:
June 30, 2026

Study Description

There is a critical need for low-cost, non-antibiotic interventions that are feasible for patients to utilize for risk reduction and prevention of recurrent urinary tract infections (UTIs). The current most effective non-antibiotic prophylaxis for recurrent UTI is vaginal estrogen; however, approximately 50% of women will continue to experience UTIs. The investigators propose a randomized control trial of postmenopausal women on vaginal estrogen with the diagnosis of recurrent UTIs to evaluate a novel post-defecation hygienic strategy utilizing a 2% chlorhexidine perineal lavage. Participants will be randomized to either a 2% chlorhexidine perineal lavage or a water lavage. Study participants will be followed for up to 6-months, and UTIs will be tracked with culture proven samples throughout study participation.

Connect with a study center

  • Oregon Health & Science University

    Portland, Oregon 97239
    United States

    Site Not Available

  • Oregon Health & Science University

    Portland 5746545, Oregon 5744337 97239
    United States

    Site Not Available

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