A Ketamine-assisted Group Therapy Intervention for Spanish-speaking Adults With Depression

Inclusion Criteria:

1. Self-identifying Latinx, Spanish-speaking 2. Adults 18-64 years 3. Meet DSM-5criteria for major depressive disorder as evaluated by study clinician 4.Montgomery-Asberg depression scale (MADRS) score of 20 or above at baseline 4.Participants must have an MGB psychiatrist and primary care provider.

Exclusion Criteria:

1. History of primary psychotic disorder, by history

2. History Bipolar I disorder, by history

3. Unstable complex PTSD, as assessed by study clinician

4. History of dissociative identity disorder

5. History of neurocognitive disorder

6. History of severe and/or recent substance use disorder, by history and as assessedby study clinician after clinical evaluation and interview

7. Uncontrolled hypertension, tachycardia, or unstable cardiopulmonary disease, byhistory a. Blood pressure on initial screen must be <140/90 mmHg.

8. History of aortic dissection

9. History of myocardial infarction

10. History of aneurysm

11. History of hepatic impairment.

12. History of epilepsy

13. History of prior hypersensitivity to ketamine

14. Body Mass Index greater than 35

15. Body Mass Index less than 18.5

16. Are pregnant, breastfeeding, or planning to become pregnant within 12 weeks oftreatment completion

17. Enrolled in other clinical trial for the treatment of depression or other behavioralhealth diagnosis

18. Inability to provide consent.