A Study in Participants With Obesity or Overweight With at Least One Weight-related Comorbidity

Last updated: May 15, 2025
Sponsor: AstraZeneca
Overall Status: Active - Not Recruiting

Phase

2

Condition

Obesity

Diabetes Prevention

Hypertriglyceridemia

Treatment

AZD6234

Placebo comparator

Clinical Study ID

NCT06595238
D8750C00004
2024-514000-13-00
  • Ages 18-75
  • All Genders

Study Summary

A Phase IIb Randomised, Double-blind, Placebo-controlled Study to Evaluate the Efficacy, Safety and Tolerability of AZD6234 compared with placebo, given once a week as subcutaneous injection for 36 weeks, in male and female participants of at least 18 years of age who are living with obesity (body mass index [BMI] ≥ 30 kg/m2), or overweight (BMI ≥ 27 kg/m2) and at least one weight-related comorbidity

Eligibility Criteria

Inclusion

Inclusion Criteria:

  • Adults ≥ 18 years of age

  • BMI of (a) ≥ 30 kg/m2, or (b) ≥ 27kg/m2 and have a current diagnosis of at least 1weight-related comorbidities (treated or untreated)

  • A stable body weight for 3 months prior to Screening (±5% body weight change)

Exclusion

Exclusion Criteria:

  • Have obesity induced by other endocrine disorders, such as Cushing's syndrome orPrader-Willi syndrome

  • Has received prescription or non-prescription medication for weight loss within thelast 3 months prior to Screening

  • Previous or planned (within study period) bariatric surgery or fitting of a weightloss device (eg, gastric balloon or duodenal barrier)

  • History of type 1 diabetes mellitus or T2DM

Study Design

Total Participants: 262
Treatment Group(s): 2
Primary Treatment: AZD6234
Phase: 2
Study Start date:
October 01, 2024
Estimated Completion Date:
December 08, 2025

Study Description

The study will comprise of:

A screening period of maximum 28 days

A treatment period of 36 weeks

A follow up period after last dose of study drug

This study will consist of 4 cohorts. Approximately 231 eligible participants will be randomized to AZD6234 or placebo

Connect with a study center

  • Research Site

    Heidelberg West, 3081
    Australia

    Site Not Available

  • Research Site

    Maroochydore, 4556
    Australia

    Site Not Available

  • Research Site

    Maroubra, 2035
    Australia

    Site Not Available

  • Research Site

    Merewether, 2291
    Australia

    Site Not Available

  • Research Site

    Hamilton, Ontario L8L 5G8
    Canada

    Site Not Available

  • Research Site

    Sarnia, Ontario N7T 4X3
    Canada

    Site Not Available

  • Research Site

    Stouffville, Ontario L4A1H2
    Canada

    Site Not Available

  • Research Site

    Toronto, Ontario M3J 2C5
    Canada

    Site Not Available

  • Research Site

    Montreal, Quebec H4N 2W2
    Canada

    Site Not Available

  • Research Site

    Sherbrooke, Quebec J1L 0H8
    Canada

    Site Not Available

  • Research Site

    Chuo-ku, 103-0027
    Japan

    Site Not Available

  • Research Site

    Shinjuku-ku, 160-0008
    Japan

    Site Not Available

  • Research Site

    Suita-shi, 565-0853
    Japan

    Site Not Available

  • Research Site

    Krakow, 31-261
    Poland

    Site Not Available

  • Research Site

    Kraków, 31-156
    Poland

    Site Not Available

  • Research Site

    Lublin, 20-718
    Poland

    Site Not Available

  • Research Site

    Poznań, 60-589
    Poland

    Site Not Available

  • Research Site

    Warszawa, 03-291
    Poland

    Site Not Available

  • Research Site

    Airdrie, ML6 0JS
    United Kingdom

    Site Not Available

  • Research Site

    Hull, HU3 2PA
    United Kingdom

    Site Not Available

  • Research Site

    Leicester, Le5 4PW
    United Kingdom

    Site Not Available

  • Research Site

    Penarth, CF64 2XX
    United Kingdom

    Site Not Available

  • Research Site

    Rotherham, S65 1DA
    United Kingdom

    Site Not Available

  • Research Site

    Mobile, Alabama 36608
    United States

    Site Not Available

  • Research Site

    Phoenix, Arizona 85044
    United States

    Site Not Available

  • Research Site

    Long Beach, California 90815
    United States

    Site Not Available

  • Research Site

    Sacramento, California 95864
    United States

    Site Not Available

  • Research Site

    Hialeah, Florida 33012
    United States

    Site Not Available

  • Research Site

    Orlando, Florida 32825
    United States

    Site Not Available

  • Research Site

    Seminole, Florida 33777
    United States

    Site Not Available

  • Research Site

    Tampa, Florida 33606
    United States

    Site Not Available

  • Research Site

    Atlanta, Georgia 30328
    United States

    Site Not Available

  • Research Site

    Decatur, Georgia 30030
    United States

    Site Not Available

  • Research Site

    Woodstock, Georgia 30189
    United States

    Site Not Available

  • Research Site

    Indianapolis, Indiana 46260
    United States

    Site Not Available

  • Research Site

    Nottingham, Maryland 21236
    United States

    Site Not Available

  • Research Site

    Gulfport, Mississippi 39503
    United States

    Site Not Available

  • Research Site

    Ridgeland, Mississippi 39157
    United States

    Site Not Available

  • Research Site

    Kansas City, Missouri 64111
    United States

    Site Not Available

  • Research Site

    Omaha, Nebraska 68134
    United States

    Site Not Available

  • Research Site

    Portsmouth, New Hampshire 03801
    United States

    Site Not Available

  • Research Site

    Morehead City, North Carolina 28557
    United States

    Site Not Available

  • Research Site

    Statesville, North Carolina 28625
    United States

    Site Not Available

  • Research Site

    Charleston, South Carolina 29414
    United States

    Site Not Available

  • Research Site

    North Charleston, South Carolina 29405
    United States

    Site Not Available

  • Research Site

    Knoxville, Tennessee 37938
    United States

    Site Not Available

  • Research Site

    Austin, Texas 78731
    United States

    Site Not Available

  • Research Site

    Dallas, Texas 75230
    United States

    Site Not Available

  • Research Site

    Port Arthur, Texas 77642
    United States

    Site Not Available

  • Research Site

    San Antonio, Texas 78249
    United States

    Site Not Available

  • Research Site

    Hampton, Virginia 23666
    United States

    Site Not Available

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