Effect of Renal Impairment on Enpatoran Pharmacokinetics

Inclusion Criteria:

For Control Group 1 (Normal Renal Function):

• Medical history and physical examination without any ongoing clinically relevantfindings as judged by the Investigator

• No clinically relevant findings (only minor deviations) in biochemistry, hematology,coagulation, and urinalysis examinations for the age of the participant, as judgedby the Investigator; absolute lymphocyte count and absolute neutrophil count must bewithin normal limits

For Group 2 (Impaired Renal Function):

• Medical history and physical examination without any ongoing clinically relevantfindings except for the underlying disease leading to renal impairment andconsequence diseases thereof

• Chronic kidney disease

• For participants under medication, stable medication for at least 1 month

• Other protocol defined inclusion criteria could apply

Exclusion Criteria:

• History or presence of respiratory, gastrointestinal (including bariatric or othergastric surgeries, or other conditions that may affect drug absorption), hepatic (including hepatorenal syndrome), hematological, lymphatic, cardiovascular (such asventricular dysfunction and congestive heart failure, cardiac arrythmia),psychiatric, neurological, genitourinary, immunological, dermatological, connectivetissue diseases, or disorders that may affect the safety of the participant.

• History of drug hypersensitivity, ascertained or presumptiveallergy/hypersensitivity to the active drug substance and/or formulationingredients; history of serious allergic reactions leading to hospitalization or anyother hypersensitivity reaction in general, which may affect the safety of theparticipant and/or outcome of the study per the Investigator's discretion

• History or presence of epilepsy, neurological disorders with seizure propensity orundiagnosed loss of consciousness, severe head trauma within 6 months or severedepression within 12 months prior to Screening), or neuropsychiatric conditions

• History of serotonin syndrome

• Prior history of cholecystectomy or splenectomy, and any clinically relevant surgerywithin 6 months prior to Screening, which might interfere with the objectives of thestudy or the study procedures

• Other protocol defined exclusion criteria could apply