Single and Multiple Ascending Dose Study of AMG 513 in Participants With Obesity

Inclusion Criteria:

• Participants in the study will be males and females 18 to 65 years of age at thetime of signing the informed consent with a body mass index (BMI) of 30.0 kg/m^2 to 40.0 kg/m^2 for Part A and BMI of 27.0 kg/m^2 to 40.0 kg/m^2 for Part B.

• Females enrolled must be of non-childbearing potential.

Exclusion Criteria:

• History and/or clinical evidence of diabetes mellitus, including hemoglobin A1c ≥ 6.5% and/or a fasting glucose of ≥ 126 mg/dL (7 mmol/L) at screening.

• Triglycerides ≥ 5.65 mmol/L (i.e., 500 mg/dL) at screening.