Evaluation of Suvorexant for Reduction of Brain Reactivity in Patients With Cannabis Use Disorder (Pilot Study)

Inclusion Criteria:

• Age 18-60 years, inclusive

• Use cannabis daily or near daily and have been using cannabis consistently for atleast the past year, by self-report

• Meet criteria for cannabis use disorder (CUDIT-R scores greater than or equal to 8)

• Female participants of childbearing potential must have a negative pregnancy test atthe enrollment visit

• Be able to read, speak, and understand the English language. English can be a secondlanguage, provided that the subject understands all the questions used in theassessment measures.

• Access to a mobile device to complete daily surveys

Exclusion Criteria:

• Participants cannot have an acutely unstable medical or psychiatric illness

• Medications with the potential to depress CNS function will be assessed by the PI orstudy physician and participants will be excluded as necessary

• Participants cannot have a history of major head trauma resulting in cognitiveimpairment, seizure, or other neurological disorders

• Presence of metallic foreign bodies such as cardiac pacemakers, perfusion pumps,aneurysm clips, metallic tattoos anywhere on the body, tattoos near the eye

• Individuals with severe hepatic impairment will be excluded

• Participants cannot be obese as determined by a Body Mass Index (BMI) or greaterthan 35

• Participants cannot be using a CYP3A inhibitor/inducer (metabolism by CYP3A is themajor elimination pathway for suvorexant)

• Participants cannot have a current cardiac disorder such as palpitations,tachycardia, and/or the use of the cardiac medication Digoxin

• Participants cannot have narcolepsy

• Participants cannot self-report complex sleep behaviors such as sleep driving,preparing and eating food, or making phone calls

• Participants cannot be actively suicidal (current suicidal ideation with specificplan or intent) and/or report a suicide attempt or psychiatric hospitalization inthe past year

• Participants cannot have a current substance use disorder based on a DSM-V diagnosisand MINI Interview for Substance Use Disorders other than nicotine and cannabis andcannot meet criteria for moderate or severe alcohol use disorder

• Pregnancy or breastfeeding: a negative pregnancy test is required at the enrollmentvisit

• In the opinion of the investigators, not able to complete study procedures or safelyparticipate in the study