A Study of Orforglipron for the Maintenance of Body Weight Reduction in Participants Who Have Obesity or Overweight With Weight-Related Comorbidities (ATTAIN-MAINTAIN)

Last updated: February 27, 2025
Sponsor: Eli Lilly and Company
Overall Status: Active - Enrolling

Phase

3

Condition

Weight Loss

Diabetes Prevention

Obesity

Treatment

Orforglipron

Placebo

Clinical Study ID

NCT06584916
27239
J2A-MC-GZPN
  • Ages > 18
  • All Genders

Study Summary

The main purpose of this study is to evaluate the efficacy and safety of orforglipron on maintenance of body weight reduction.

Eligibility Criteria

Inclusion

Inclusion Criteria:

  • Have completed the SURMOUNT-5 study on study treatment

Exclusion

Exclusion Criteria:

  • Have Type 1 Diabetes, Type 2 Diabetes, or any other types of diabetes, history ofketoacidosis, or hyperosmolar state/coma

  • Have a prior or planned surgical treatment for obesity

  • Have acute or chronic hepatitis

  • Have a history of acute or chronic pancreatitis

Study Design

Total Participants: 300
Treatment Group(s): 2
Primary Treatment: Orforglipron
Phase: 3
Study Start date:
September 13, 2024
Estimated Completion Date:
January 31, 2026

Study Description

All enrolled participants will have completed SURMOUNT-5 (I8F-MC-GPHJ; NCT05822830) on treatment and meet further eligibility and randomization criteria. All endpoints for this study will be evaluated separately per each intervention arm of SURMOUNT-5.

Connect with a study center

  • Puerto Rico Medical Research

    Ponce, 00717
    Puerto Rico

    Site Not Available

  • Wellness clinical Research Vega Baja

    Vega Baja, 00694
    Puerto Rico

    Site Not Available

  • Cahaba Research

    Birmingham, Alabama 35242
    United States

    Site Not Available

  • Cahaba Research - Pelham

    Pelham, Alabama 35124
    United States

    Site Not Available

  • Southern California Dermatology, Inc.

    Santa Ana, California 92701
    United States

    Site Not Available

  • Encompass Clinical Research

    Spring Valley, California 91978
    United States

    Site Not Available

  • University Clinical Investigators, Inc.

    Tustin, California 92780
    United States

    Site Not Available

  • New Horizon Research Center

    Miami, Florida 33165
    United States

    Site Not Available

  • Rophe Adult and Pediatric Medicine/SKYCRNG

    Union City, Georgia 30291
    United States

    Site Not Available

  • Rocky Mountain Clinical Research

    Idaho Falls, Idaho 83404
    United States

    Site Not Available

  • Iowa Diabetes and Endocrinology Research Center

    West Des Moines, Iowa 50265
    United States

    Site Not Available

  • L-MARC Research Center

    Louisville, Kentucky 40213
    United States

    Site Not Available

  • Arcturus Healthcare , PLC, Troy Internal Medicine Research Division

    Troy, Michigan 48098
    United States

    Site Not Available

  • Prime Health and Wellness/SKYCRNG

    Fayette, Mississippi 39069
    United States

    Site Not Available

  • StudyMetrix Research

    Saint Peters, Missouri 63303
    United States

    Site Not Available

  • Palm Research Center Sunset

    Las Vegas, Nevada 89148
    United States

    Site Not Available

  • Palm Research Center Tenaya

    Las Vegas, Nevada 89128
    United States

    Site Not Available

  • Weill Cornell Medical College

    New York, New York 10021
    United States

    Site Not Available

  • PharmQuest Life Sciences, LLC

    Greensboro, North Carolina 27408
    United States

    Site Not Available

  • Lillestol Research

    Fargo, North Dakota 58104
    United States

    Site Not Available

  • Alliance for Multispecialty Research, LLC

    Norman, Oklahoma 73069
    United States

    Site Not Available

  • Tribe Clinical Research, LLC

    Greenville, South Carolina 29607
    United States

    Site Not Available

  • WR-Clinsearch, LLC

    Chattanooga, Tennessee 37421
    United States

    Site Not Available

  • General Surgery MIST Division Loc. 4

    Bellaire, Texas 77401
    United States

    Site Not Available

  • The University of Texas Health Science Center at Houston

    Bellaire, Texas 77401
    United States

    Site Not Available

  • North Texas Endocrine Center

    Dallas, Texas 75231
    United States

    Site Not Available

  • Velocity Clinical Research, Dallas

    Dallas, Texas 75230
    United States

    Site Not Available

  • Biopharma Informatic, LLC

    Houston, Texas 77043
    United States

    Site Not Available

  • PlanIt Research, PLLC

    Houston, Texas 77079
    United States

    Site Not Available

  • Southern Endocrinology Associates

    Mesquite, Texas 75149
    United States

    Site Not Available

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