Aging, Beta Blockers, and Thermoregulatory Responses

Last updated: October 18, 2024
Sponsor: University of Texas Southwestern Medical Center
Overall Status: Active - Recruiting

Phase

4

Condition

Aging

Treatment

Ambient Heat

Metoprolol

Propranolol

Clinical Study ID

NCT06582680
STU-2024-0644
  • Ages > 65
  • All Genders
  • Accepts Healthy Volunteers

Study Summary

This study will test the hypothesis that the drugs propranolol and metoprolol will result in greater increases in core body temperature during 3 hours of extreme heat exposure in older adults.

Eligibility Criteria

Inclusion

Inclusion Criteria:

  • Healthy and free of any significant medical problems

  • Normal resting electrocardiogram

  • 65+ years of age

  • Controlled cholesterol of less than 200 mg/dl

  • Controlled blood pressure of less than 140/90 mmHg

Exclusion

Exclusion Criteria:

  • Known diseases or other chronic conditions requiring regular medical therapyincluding cancer, diabetes, neurological diseases, uncontrolled hypertension, anduncontrolled hypercholesterolemia

  • Serious abnormalities detected on routine screening

  • Taking prescribed medications or over-the-counter medications that have knowninfluences on either cardiac function or sweating

  • Current smokers, as well as individuals who regularly smoked within the past 3 years

  • body mass index ≥31 kg/m2

Study Design

Total Participants: 22
Treatment Group(s): 4
Primary Treatment: Ambient Heat
Phase: 4
Study Start date:
October 04, 2024
Estimated Completion Date:
September 30, 2026

Study Description

Older individuals are more likely to die or become ill during heat waves. During the 1995 Chicago heat wave, there was 35% increase in hospital admissions for individuals older than 65 years of age. Moreover, adults over the age of 65 have a heat-related death rate that is more than double any other age group. Therefore, with an increasing elderly population that is expected to rise by 60% (to 78 million) by 2035, the causes of this excess mortality must be understood to better protect the ageing United States population. It is notable that selective and non-selective beta blocker drugs are commonly prescribed to older individuals with cardiovascular diseases. In younger individuals exposed to a heat stress, beta blocker administration reduced whole-body sweat rate and skin blood flow responses resulting in greater increases in core body temperature. Notably, nothing is known regarding the effects of beta blockers on thermoregulatory responses during heat exposure in older individuals.

This project will evaluate core body temperature responses to selective and non-selective beta blocker drugs during simulated heat wave exposure in older individuals.

Connect with a study center

  • IEEM Texas Health Presbyterian Hospital Dallas

    Dallas, Texas 75231
    United States

    Active - Recruiting

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