Clinical Trial of Aesculus Hippocastanum and Associations Versus Diosmina and Hesperidina in Chronic Venous Insuficiency

Inclusion Criteria:

1. Patient presenting CEAP classification from grade C0 to C3 in the evaluation ofvenous disease of the lower limbs

2. Clinical symptoms of chronic venous insufficiency of the lower limbs, defined by the 100mm visual scale performed by the patient between 20mm and 60mm in the mostsymptomatic lower limb.

3. For female patients of reproductive age, not pregnant or breastfeeding, usingreliable contraceptives.

4. Patient read, understood, signed and dated the free and informed consent form

Exclusion Criteria:

1. Treatment with compression stockings within 2 months of study inclusion date

2. Treatment with venotonics within 2 months of the date of inclusion in the study

3. Women of reproductive age who are pregnant or breastfeeding, or who do not wish touse contraception during the study period.

4. Known allergy or hypersensitivity to any component of the study drug

5. Known significant laboratory abnormality

6. CEAP Grade Assessment of level 4, 5, or 6.

7. Patient with venous disease requiring intravenous chemical surgery/sclerotherapy

8. Patient presenting with a painful pathology in addition to venous pain in the lowerlimbs 9. Patient with a history of thrombosis or thromboembolic disease within 6months of the date of inclusion in the study

9. Patient with a change in general condition that is incompatible with his/herparticipation in the study 11. Patient who wishes to become pregnant within 6 months