Effects of AZD5004 in Adults Who Are Living With Obesity or Overweight With at Least 1 Weight-related Comorbidity

Inclusion Criteria:

• Adults ≥ 18 years of age.

• BMI of (a) ≥ 30 kg/m2, or (b) ≥ 27 kg/m2 and have a current diagnosis of at least 1of the following weight-related comorbidities (treated or untreated):

(i) Hypertension (ii) Dyslipidemia or hyperlipidemia (iii) CV disease (iv)Obstructive sleep apnea

• A stable body weight for 3 months prior to Screening (± 5% body weight change).

Exclusion Criteria:

• Have obesity induced by other endocrine disorders, such as Cushing's syndrome ormonogenic or syndromic obesity such as Prader-Willi syndrome.

• Has received prescription or non-prescription medication for weight loss within thelast 3 months prior to Screening.

• Previous or planned (within study period) bariatric surgery or fitting of a weightloss device (eg, gastric balloon or duodenal barrier).

• History of type 1 diabetes mellitus or type 2 diabetes mellitus.

• Clinically significant inflammatory bowel disease, gastroparesis, severe disease, orsurgery affecting the upper GI tract.

• History of acute or chronic pancreatitis.