Prednisone Plus IVIg vs. Prednisone for ITP During Pregnancy

Inclusion Criteria:

1. Age 18-50 years old;

2. Meet the diagnostic criteria for immune thrombocytopenia;

3. Pregnant women with ITP without ITP-specific treatments during pregnancy;

4. Gestational weeks ≥12 weeks;

5. Platelet count <30×10^9/L, accompanied with or without bleeding symptoms.

6. Willing and able to sign written informed consent.

Exclusion Criteria:

1. Have a known diagnosis of other autoimmune diseases, confirmed medical history orlaboratory findings within positive anti-nuclear antibodies (>1:80),anti-cardiolipin antibodies, lupus anticoagulant factors or direct Coombs' test.

2. Thrombocytopenia caused by pregnancy-specific conditions, such as gestationalthrombocytopenia, preeclampsia, the HELLP syndrome and acute fatty liver ofpregnancy.

3. Secondary thrombocytopenia such as drug-related thrombocytopenia, vaccine-relatedthrombocytopenia, lymphoproliferative disorders, severe infection, hepatic cirrhosisand so on.

4. With other underlying diseases that may cause thrombocytopenia, such as: malignantdisease, megaloblastic anemia, aplastic anemia, myelodysplasia syndrome, myeloidfibrosis, disseminated intravascular coagulation, thrombotic thrombocytopenicpurpura, Hemolytic uremic syndrome, disseminated intravascular coagulation and soon;

5. Current HIV infection or hepatitis B virus or hepatitis C virus infections;

6. With severe heart, kidney, liver or respiratory dysfunction;

7. With the medical history of mental illness;

8. Have allergic reaction to prednisone or IVIg;