Phase
Condition
Knee Injuries
Osteoarthritis
Treatment
Topical Diclofenac gel
Topical Diclofenac gel 1%
Clinical Study ID
Ages > 50 All Genders
Study Summary
Eligibility Criteria
Inclusion
Inclusion Criteria:
English-speaking
50 years of age or older
Radiographically confirmed knee OA of K/L grade 2 or higher within the past 2 years
Knee pain at least 15 days/month.
Average worst daily pain 3/10 or higher over a two-week period.
Exclusion
Exclusion Criteria:
Medical contraindication to taking NSAIDs such as: history of coronary artery bypassgraft, myocardial infarction, coronary artery stent placement, or stroke within thepast 6 months; systolic heart failure with ejection fraction <45%; chronic kidneydisease stage ≥4; severe gastrointestinal bleed or stomach ulcer within the past 6months; current pregnancy; cirrhosis; currently taking blood thinners (aspirin 81 mgdaily is okay); allergy to NSAIDs or aspirin; or any other medical contraindicationto using topical NSAIDs.
Inflammatory arthritis
Partial or total knee replacement of the index knee
Recent therapeutic injection of the index knee (less than 12 weeks)
Planned knee/lower limb surgery during the two-month study period
Active cancer treatment not in remission or life expectancy less than 6 months
Inability to provide informed consent (e.g. dementia)
Current use of topical or oral NSAIDs more than 3 days per week.
Inability to receive text messages or emails to complete questionnaires betweenstudy visits.
Unable to follow the study protocol.
Study Design
Study Description
Connect with a study center
University of California Davis Health
Sacramento, California 95817
United StatesActive - Recruiting


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