Safety and Efficacy of Meplazumab in Patients With Coronary Artery Disease

Inclusion Criteria:

1. Patients with chronic coronary syndrome

2. Non-target lesions with stenosis ≥50% by visual assessment

3. Angina symptoms manageable via antianginal medication

4. High attenuation coefficient (≥-70.1 HU) of perivascular adipose tissue (PVAT)around non-target lesions as assessed by coronary CT angiography (CCTA)

5. Patients who are able to complete the follow-up and compliant to the prescribedmedication

Exclusion Criteria:

1. Under the age of 18

2. Unable to give informed consent or currently participating in another trial and notyet at its primary endpoint

3. Patient is a woman who is pregnant or nursing (a pregnancy test must be performedwithin 7 days prior to the index procedure in women of child-bearing potentialaccording to local practice)

4. Concurrent medical condition with a life expectancy of less than 3 years

5. Haemodynamical unstable

6. Known contraindications to medications such as test drug and its components,heparin, or contrast

7. The following criteria are met for any of the laboratory test indicators at the timeof screening ①ALT/AST >3ULN；②TBil ≥2ULN；③WBC>2ULN；④NEUT<0.5×109 /L；⑤PLT<30×109 /L；⑥eGFR &amp;lt;60 mL/min/1.73 m2（CKD-EPI formula）

8. Suffering from severe systemic diseases, tumors, immune system disorders,infections, malignancy, which in the opinion of the investigator make participationin this study inappropriate