Phase
Condition
Connective Tissue Diseases
Treatment
Topical Product: Almond oil augmented with 0.5% Vitamin E
Topical Product: 0.025% Tretinoin oil augmented with castor oil
Topical Product: Almond Oil
Clinical Study ID
Ages > 18 Female Accepts Healthy Volunteers
Study Summary
Eligibility Criteria
Inclusion
Inclusion Criteria:
Post-menopausal women of Fitzpatrick skin types 1, 2, and 3
Individuals with facial fine lines and wrinkles
Exclusion
Exclusion Criteria:
Individuals who are pregnant or breastfeeding
Prisoners
Adults unable to consent
Those with a nut allergy or tocopherol allergy
Current smokers, those that have smoked within the past year, and former smokerswith greater than a 10-pack- year history of smoking
Those with an autoimmune photosensitive condition or a known genetic condition witha deficiency in collagen production (such as Ehlers-Danlos syndromes)
Those who have undergone any cosmetic procedures to the face in the 3 months priorto enrollment in the opinion of the investigator. People that have undergone deeperchemical peels (TCA based peels) within 1 year prior to enrollment
Individuals who are unwilling to discontinue vitamin E containing supplements andfood sources such as all nuts, sunflower seeds or sunflower oil during the washoutand intervention
Individual who are unwilling to discontinue topical cosmetic products during theduration of the study or unwilling to undergo a 2-week washout of topicals that areknown to modulate collagen and pigment:
Retinoids such as tretinoin, adapalene, retinol, except as provided by the study.
Antioxidant ingredients such as vitamin C or vitamin E.
Pigment reducing agents such as hydroquinone, azelaic acid, kojic acid, or aretinoid except for the retinol that is provided in this study.
Topicals that contain a nut oil or nut extract as part of their ingredient list.
Study Design
Study Description
Connect with a study center
Integrative Research Institute
Sacramento, California 95819
United StatesActive - Recruiting
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