The Effects of Topical Almond Oil and Tretinoin on Facial Wrinkles

Last updated: August 26, 2024
Sponsor: Integrative Skin Science and Research
Overall Status: Active - Recruiting

Phase

N/A

Condition

Connective Tissue Diseases

Treatment

Topical Product: Almond oil augmented with 0.5% Vitamin E

Topical Product: 0.025% Tretinoin oil augmented with castor oil

Topical Product: Almond Oil

Clinical Study ID

NCT06571721
IRI24_01_AlmondOil
  • Ages > 18
  • Female
  • Accepts Healthy Volunteers

Study Summary

Investigate the topical use of almond oil, almond oil augmented with 0.5% vitamin E, 0.025% tretinoin oil augmented with castor oil on the appearance of facial fine lines and wrinkles, pigmentation, hydration, trans-epidermal water loss, and sebum excretion rate.

Eligibility Criteria

Inclusion

Inclusion Criteria:

  • Post-menopausal women of Fitzpatrick skin types 1, 2, and 3

  • Individuals with facial fine lines and wrinkles

Exclusion

Exclusion Criteria:

  • Individuals who are pregnant or breastfeeding

  • Prisoners

  • Adults unable to consent

  • Those with a nut allergy or tocopherol allergy

  • Current smokers, those that have smoked within the past year, and former smokerswith greater than a 10-pack- year history of smoking

  • Those with an autoimmune photosensitive condition or a known genetic condition witha deficiency in collagen production (such as Ehlers-Danlos syndromes)

  • Those who have undergone any cosmetic procedures to the face in the 3 months priorto enrollment in the opinion of the investigator. People that have undergone deeperchemical peels (TCA based peels) within 1 year prior to enrollment

  • Individuals who are unwilling to discontinue vitamin E containing supplements andfood sources such as all nuts, sunflower seeds or sunflower oil during the washoutand intervention

  • Individual who are unwilling to discontinue topical cosmetic products during theduration of the study or unwilling to undergo a 2-week washout of topicals that areknown to modulate collagen and pigment:

  • Retinoids such as tretinoin, adapalene, retinol, except as provided by the study.

  • Antioxidant ingredients such as vitamin C or vitamin E.

  • Pigment reducing agents such as hydroquinone, azelaic acid, kojic acid, or aretinoid except for the retinol that is provided in this study.

  • Topicals that contain a nut oil or nut extract as part of their ingredient list.

Study Design

Total Participants: 90
Treatment Group(s): 3
Primary Treatment: Topical Product: Almond oil augmented with 0.5% Vitamin E
Phase:
Study Start date:
July 22, 2024
Estimated Completion Date:
July 22, 2025

Study Description

The natural cosmetic market is a multi-billion dollar industry. Nutraceuticals and food-based cosmetics are a growing trend within dermatology. Almonds are a rich dietary source of a range of fatty acids, phytochemical polyphenols, and antioxidants. Our previous study was a double blinded study that compared almond consumption interventions to a calorie matched intervention over 16 weeks. The study determined that that there was a statistically significant 8.41% improvement in wrinkle severity in the women that received almond supplementation. This proposal aims to now understand how the topical application of almond oil may influence the appearance of wrinkles and facial tone in post-menopausal women. Almond oil is rich in fatty acids and alpha-tocopherol. Tocopherol inhibits melanogenesis in melanocytes and topical alpha tocopherol has been shown to improve skin antioxidants and hyperpigmentation. A challenge of almond oil is that it is prone to oxidation due to its high unsaturated fatty acid concentrations. However, tocopherol has also been shown to improve almond oil stability.

Connect with a study center

  • Integrative Research Institute

    Sacramento, California 95819
    United States

    Active - Recruiting

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