IGNITE Firefighters' Health

Inclusion Criteria:

• Age 18+

• Active SF firefighter

• Willing to consume a plant-based diet (vegetables, fruit, whole grains, legumes,etc.)

• Willing to complete 4 clinic visits

Exclusion Criteria:

• Weight < 110 lb

• BMI >= 40

• Self-reported uncontrolled hypercholesterolemia, hypertension or diabetes

• Pregnant, lactating, or planning to become pregnant during the course of the study.

• Use of any of the following drugs/supplements within the last 2 months:

• systemic antibiotics, antifungals, antivirals, or antiparasitics (intravenous,intramuscular, or oral);

• corticosteroids (intravenous, intramuscular, oral, nasal or inhaled);

• cytokines;

• methotrexate or immunosuppressive cytotoxic agents.

• Chronic, clinically significant, or unstable (unresolved, requiring ongoing changesto medical management or medication) pulmonary, cardiovascular, gastrointestinal,hepatic or renal functional abnormality, as determined by medical history, Type 1diabetes, dialysis

• History of active cancer in the past 3 years except for squamous or basal cellcarcinomas of the skin that have been medically managed by local excision

• Unstable dietary history as defined by major changes in diet during the previousmonth, where the subject has eliminated or significantly increased a major foodgroup in the diet.

• Recent history of chronic excessive alcohol consumption defined as more than five 1.5-ounce servings of 80 proof distilled spirits, five 12-ounce servings of beer orfive 5-ounce servings of wine per day; or > 14 drinks/week.

• Any confirmed or suspected condition/state of immunosuppression or immunodeficiency (primary or acquired) including HIV infection, multiple sclerosis, and Graves'disease.

• Surgery of the GI tract, with the exception of cholecystectomy and appendectomy, inthe past five years. Any major bowel resection at any time.

• Regular/frequent use of smoking or chewing tobacco, e-cigarettes, cigars or othernicotine-containing products

• Regular use of prescription opiate pain medication