The Immediate Effect of Combined Terminal Knee Extension Exercise With Audible Cues

Last updated: July 25, 2025
Sponsor: Mahidol University
Overall Status: Completed

Phase

N/A

Condition

Polymyositis (Inflammatory Muscle Disease)

Sarcopenia

Treatment

Exercise

Exercise + Audible Cues

Clinical Study ID

NCT06565325
MU-CIRB 2024/021.0802
  • Ages 18-30
  • All Genders

Study Summary

Typically, patients perform TKE by themselves after exercise prescription. The investigators thought that a lack of attention and preferred speed of patients might not provide the best outcome. Therefore, an increased effectiveness of TKE is interesting for physical therapy implication. Besides, adding sensory input which is audible cues or rhythm during exercise may enhance the efficacy of the exercise by increasing neuromuscular control and function.

Therefore, the study aimed to investigate the immediate effects of combined TKE with audible cues on motor unit behavior. The researchers expect that adding rhythm from the metronome will enhance neuromuscular control which may change motor unit behavior of VM muscle. The findings of the study may have helped explain the mechanism behind the acute effects of combined TKE with audible cues on VM function and their potential application in the field of physical therapy.

This study aims to investigate the immediate effect of combined TKE with audible cues on motor unit behavior in healthy participants and to investigate reliability of decomposition electromyography procedure during single leg squat.

Eligibility Criteria

Inclusion

Inclusion Criteria:

  • Aged range between 18 and 30 years

  • BMI of 18.5-25 kg/m2

  • Male or female

  • Lightly active or sedentary {Physical activity level (PAL= 1.4-1.69)}

Exclusion

Exclusion Criteria:

  • History of serious injury or operation of lower back and lower extremities such asfracture

  • Musculoskeletal problems of lower back and lower extremities in 6 months before thestudy

  • Single-leg stance test < 43 seconds (26). and range of weight-bearing lunge test < 9.1 cm

Study Design

Total Participants: 30
Treatment Group(s): 2
Primary Treatment: Exercise
Phase:
Study Start date:
February 10, 2024
Estimated Completion Date:
March 07, 2025

Study Description

A metronome will be used to provide rhythmic exercise. Participants will stand with their feet in line with their shoulders as starting position and straping at the knee. Exercise intensity is 60% of the 1RM weight. At the beginning of the exercise, participants will be asked to bend their knees following the pull of the resistance and exert force to straighten the knee (10 times/set and 3 sets). 180 seconds of resting will be allowed between sets.

Connect with a study center

  • Faculty of Physical Therapy, Mahidol University

    Nakhon Pathom, Salaya 73170
    Thailand

    Site Not Available

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