Neurofeedback Enhanced Cognitive Reappraisal Training - Phase 4

Inclusion Criteria:

• Primary diagnosis (primary source of distress and/or interference) of generalizedanxiety disorder, social anxiety disorder, panic disorder or illness anxietydisorder based on structured interview. Comorbid phobic disorders allowed, but thesecannot be the primary source of interference or distress due to the lowered chancesof encountering anxiety-provoking stimuli during the study period

• Score of 2 or more on at least 1 question from GAD/CROSS-AD composite

• Medically and physically able to consent

• Not regularly taking any medication, prescription or non-prescription, withpsychotropic effects other than:

1. Buspirone, or antidepressant (e.g., selective serotonin reuptake inhibitor (SSRI) or serotonin-norepinephrine reuptake inhibitor (SNRI)) with stabledosage for past 4 weeks

2. The same oral hormonal contraceptive for at least 3 months

• For females, not currently pregnant or actively trying to become pregnant

• Ability to tolerate small, enclosed spaces without anxiety

• No metals, implants or metallic substances within or on the body that might causeadverse effects to the subject in a strong magnetic field, or interfere with imageacquisition (per protocol)

• Size compatible with scanner gantry (per protocol)

Exclusion Criteria:

• Current diagnosis of Obsessive Compulsive Disorder, Posttraumatic Stress Disorder,or Bipolar Disorder

• Current substance abuse or dependence (past 6 months)

• Active suicidality with plan or intent

• Current psychosis

• History of serious neurological illness or current medical condition that couldcompromise brain function, such as liver failure

• History of closed head injury, e.g., loss of consciousness greater (>) approximately (~) 5 minutes, hospitalization, neurological sequela