A Study of LY3532226 in Participants With Obesity

Inclusion Criteria:

• Have a body weight not exceeding 150 kilograms (kg) or 330 pounds (lb) and body massindex (BMI) within the range of 30 to 40 kilogram per square meter (kg/m²)

• Have had a stable body weight that is less than or equal to 5% change in body weightfor 3 months prior to screening and enrollment

Exclusion Criteria:

• Have a lifetime history of a suicide attempt

• Have a history or presence of psychiatric disorders, including a history of majordepressive disorder within the last 2 years

• Have a baseline Patient Health Questionnaire-9 (PHQ-9) score of 15 or greater,and/or a score of 2 or greater for either of the first 2 questions on the PHQ-9questionnaire

• Have a known clinically significant gastric emptying abnormality, have undergonegastric bypass surgery or restrictive bariatric surgery

• Have taken approved or investigational medication for weight loss, within theprevious 3 months or 5 half-lives of study screening, whichever is earlier

• Intend to use any weight-loss medications during study participation

• Have obesity induced by other endocrinologic disorders or diagnosed monogenetic orsyndromic forms of obesity