Currently, the EXOMA2 study (NCT04614480) offers earlier and more comprehensive exome
analysis in the management of cancer patients than EXOMA. Based on the active EXOMA2
patient file, the INFOGene study offers the opportunity to study patient-physician
communication, to assess patient preferences with regard to different information
modalities concerning theranostic exome analysis, and to reflect on information
modalities to ensure optimal patient comprehension of the information provided.
The qualitative cross-sectional study includes a dual observational and interventional
component involving cancer patients. The patients will come from the EXOMA 2 active file
at Dijon University Hospital and the CGFL.
Phase 1 will aim to observe and analyze interpersonal communication between physicians
prescribing theranostic exome analysis and cancer patients. It will be based on:
1/ ethnographic exploratory observations of 10 consultations during which the doctor will
suggest that the patient undergo theranostic exome analysis, and 2/ semi-directed
interviews with 10 new patients who have previously seen the doctor.
The patients will come from the EXOMA 2 active file at Dijon University Hospital and the
CGFL.
Step 1a : - construction of a consultation observation grid (based on existing
literature) / - identification and inclusion of patients and physicians observed
Step 1b : Observation of 10 consultations with a varied panel of prescribing
physicians, taking into account taking into account gender, age, specialty and a
heterogeneous sample of patients in socio-demographic and clinical terms
Step 1c : semi-structured interview within 10 days of the consultation with
consultation with 10 other patients by an SHS researcher to assess the degree of of
the information provided by the doctor and whether it can be used to respond to the
patient's needs.
Step 1d : thematic content analysis
Phase 2 will consist in revisiting existing information supp orts (genetic counselor's
explanatory note and and video). These materials will serve as a basis for work, and can
be adapted according to the needs of the client.
Phase 3 will aim to evaluate patients' preferences with respect to 3 information
modalities concerning a theranostic exome analysis.
Step 3a: medical consultation, during which the doctor will provide each of the 60
patients with the standard form of information reworked by the in phase 2
Step 3b : semi-structured interview within 10 days with researcher with 30 of the 60
patients.
Step 3c : 60 patients divided into 3 groups of 20 stratified by age, gender and
cancer site.
and cancer location, including 10 seen in interview:
one group will receive information based solely on the video previously previously
one group will receive information during a consultation
one group will receive information first via the video and then during a
consultation
Step 3d : A new semi-structured interview with the 60 patients. These interviews
will be carried out within 2 weeks of the information phase, in order to limit
memory bias but also to allow time for the patients to express themselves.