18F-FSPG PET/CT as a Non-Invasive Imaging Biomarker for Treatment Response to Chemoradiation in Esophageal Cancer

Last updated: April 7, 2025
Sponsor: M.D. Anderson Cancer Center
Overall Status: Active - Recruiting

Phase

N/A

Condition

Esophageal Disorders

Esophageal Cancer

Digestive System Neoplasms

Treatment

Non-Interventional Study

Clinical Study ID

NCT06549413
2022-0989
2022-0989
NCI-2023-04988
  • Ages > 18
  • All Genders

Study Summary

This study is being done to learn how 18F-FSPG PET/CT scan results may be related to the response to chemotherapy and radiation in patients with esophageal cancer.

Eligibility Criteria

Inclusion

Inclusion Criteria:

    • ≥ 18 years of age

  • Patients with locally advanced esophageal cancer

  • Patients with untreated documented carcinoma of the esophagus that is > 2 cmwho are going to receive systemic therapy concurrently with radiation asprimary therapy

  • Ability to provide written informed consent in accordance with institutionalpolicies

  • Female subjects of childbearing potential must have a negative serum or urinepregnancy test within 1 week of the proposed investigational PET/CT scan(s)prior to injection of the investigational radiopharmaceutical

Exclusion

Exclusion Criteria:

    • Body weight ≥ 400 pounds or body habitus or disability that will not permit theimaging protocol to be performed

  • Pregnant or lactating females

  • Have an allergy to intravenous contrast

  • eGFR < 30

Study Design

Total Participants: 60
Treatment Group(s): 1
Primary Treatment: Non-Interventional Study
Phase:
Study Start date:
August 23, 2023
Estimated Completion Date:
December 31, 2027

Study Description

PRIMARY OBJECTIVES:

I. Evaluate the ability of 18F-FSPG PET imaging to detect tumors in patients with esophageal cancer.

Connect with a study center

  • M D Anderson Cancer Center

    Houston, Texas 77030
    United States

    Active - Recruiting

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