Study on the Effect of Combined Estrogen and Progestogen Therapy on Endometrial Repair After Induced Abortion

Last updated: August 20, 2025
Sponsor: Women's Hospital School Of Medicine Zhejiang University
Overall Status: Active - Recruiting

Phase

1

Condition

Pregnancy Complications

Treatment

17β-estradiol/dydrogesterone tablets

Clinical Study ID

NCT06546397
PRO2023-3733
BJ2023YCPYJH003
  • Ages 18-40
  • Female

Study Summary

Induced abortion is a common method to terminate pregnancy, but during the operation, it is necessary to dilate the cervix and aspirate the uterine cavity. Repeated induced abortions may increase the risk of uterine damage, leading to cervical stenosis or intrauterine adhesions, thinning of the endometrium, which may affect the implantation of fertilized eggs and the development of embryos, and ultimately may lead to infertility or miscarriage. This study aims to explore the effects of combined estrogen and progesterone on endometrial repair and ovarian function recovery after induced abortion.

Eligibility Criteria

Inclusion

Inclusion Criteria:

  • Age between 18 years old (inclusive) and 40 years old (inclusive)

  • Body Mass Index (BMI) ranging from 18.5Kg/㎡ to 23.9Kg/㎡

  • Experienced at least 2 abortions or had a missed abortion

  • Confirmed gestational age of no more than 10 weeks, and the ultrasonic examinationwithin three days prior to the surgery shows a gestational sac (average of threediameters) of at least 1.0cm, with an embryo length of no more than 3.0cm

  • Normal preoperative examination results as per the "Clinical Diagnosis and TreatmentGuidelines and Technical Operation Standards: Family Planning Volume (2017Revision)"

  • Capable of regular follow-ups and willing to sign the informed consent form.

Exclusion

Exclusion Criteria:

  • Individuals with contraindications to estrogen and progesterone therapy

  • History of uterine adhesions confirmed by hysteroscopy, or a history of uterinecavity surgery or uterine malformation correction

  • Subjects who require placement of an intrauterine device or administration of oralcontraceptives or subcutaneous implants after the procedure

  • Individuals with mental status or cognitive function abnormalities who are unable tocooperate with the treatment process

  • Subjects who, in the opinion of the investigator, have potential risks or any otherfactors that may interfere with the study.

Study Design

Total Participants: 200
Treatment Group(s): 1
Primary Treatment: 17β-estradiol/dydrogesterone tablets
Phase: 1
Study Start date:
May 09, 2024
Estimated Completion Date:
December 31, 2025

Study Description

Postoperative care after induced abortion should prioritize the issue of endometrial repair. In 2021, the Family Planning Branch of the Chinese Medical Association published the "Expert Consensus on Promoting Endometrial Repair After Induced Abortion" [10], emphasizing the importance of endometrial repair for high-risk populations following induced abortion. Currently, clinically, methods to promote endometrial repair include estrogen-progestin medications, compound short-acting oral contraceptives, traditional Chinese medicine, and bioelectric stimulation. However, controversies still exist regarding endometrial repair, and selecting an effective and safe treatment plan remains crucial. This study aims to prospectively evaluate the efficacy and safety of estradiol/estradiol/dydrogesterone in endometrial repair after induced abortion through clinical research, providing a basis for endometrial repair and ovarian function recovery post-abortion.

Connect with a study center

  • Women's Hospital School Of Medicine Zhejiang University

    Hangzhou, Zhejiang 310006
    China

    Site Not Available

  • Women's Hospital School Of Medicine Zhejiang University

    Hangzhou 1808926, Zhejiang 1784764 310006
    China

    Active - Recruiting

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