Predictive Role of sTREM in Endovascular Thrombectomy Outcomes

Last updated: August 7, 2024
Sponsor: The Affiliated Hospital of Xuzhou Medical University
Overall Status: Active - Recruiting

Phase

N/A

Condition

Cerebral Ischemia

Cardiac Ischemia

Stroke

Treatment

N/A

Clinical Study ID

NCT06545591
XYFY2024-KL335-01
  • Ages > 18
  • All Genders

Study Summary

Soluble triggering receptor expressed on myeloid cells (sTREM), which reflects microglia activation, has been reported closely associated with neuronal injury and neuroinflammation. This study is to investigatethe prognostic roles of sTREM (sTREM1 and sTREM2) in patients with ischemic stroke who underwent endovascular thrombectomy (EVT).

Eligibility Criteria

Inclusion

Inclusion Criteria:

  • Patients > 18 years old.

  • Patients with acute large vessel occlusion within 24 hours of onset who will receiveendovascular treatment.

Exclusion

Exclusion Criteria:

  • Impossibility of getting a blood sample.

  • Impossibility of performing the test (Invalid results).

  • Refusal to provide the informed consent by the patient/relative.

Study Design

Total Participants: 300
Study Start date:
July 01, 2024
Estimated Completion Date:
December 31, 2027

Study Description

For acute ischemic stroke, the current treatment strategy involves timely recanalization by intravenous thrombolysis and endovascular thrombectomy (EVT). Patients receiving EVT are more likely to achieve successful revascularization and long--term functional independence compared with those receiving standard medical treatment.1 In patients receiving EVT, significant predictors of a favorable functional outcome include minor initial stroke severity, successful recanalization, and shorter onset--to--treatment time. However, unfavorable outcomes can occur even after early successful recanalization in some cases.Triggering receptors expressed on myeloid cells (TREM-1 and TREM-2) are a familyof receptors involved in the immune system expressed on a variety of innate cells of the myeloid lineage, including microglia. sTREM, which reflects microglia activation, has been reported closely associated with neuronal injury and neuroinflammation. We enrolled adult patients with stroke who received EVT, with blood sampling immediately before (T1) and after EVT (T2), and at 24 hours after EVT (T3). Non--stroke controls and patients with non--EVT stroke were also enrolled. The plasma concentration of sTREM1 and sTREM2 were analyzed by ELISA. The medical information, image findings and levels of plasma sTREM1 and sTREM2 were analyzed to clarify the association with poor functional outcome (modified Rankin Scale 4-6) at 3 months after stroke.

Connect with a study center

  • Department of Neurology

    Xuzhou, Jiangsu
    China

    Active - Recruiting

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