Evaluation of Periapical Healing Following Endodontic Microsurgery With Leukocyte and Platelet Rich Fibrin (L-PRF)

Phase

N/A

Condition

Periodontitis

Treatment

Leukocyte and Platelet Rich Fibrin

Clinical Study ID

NCT06545084

855857

Ages > 18
All Genders
Accepts Healthy Volunteers

Study Summary

The purpose of the study is to evaluate peri-radicular healing after root-end surgery using Leukocyte and Platelet Rich Fibrin. The study population includes patients diagnosed with persistent periapical pathology and scheduled for Endodontic Microsurgery at the University of Pennsylvania School of Dental Medicine, Department of Endodontics. Patients undergoing routine endodontic microsurgery and who meet the inclusion criteria will be given the opportunity to opt in to receive L-PRF in the osteotomy site to promote bone formation. Healing will be assessed radiographically and clinically at six, twelve, eighteen, and twenty-four months.

Eligibility Criteria

Inclusion

Inclusion Criteria:

Provision of signed and dated informed consent form.
Stated willingness to comply with all study procedures and availability for theduration of the study, including the follow-up visits.
Male or Female age >18 years old.
In good general health (ASA 2 or less) with no contraindications for EndodonticMicrosurgery.
Persistent endodontic periapical pathology Class A, B, or C according to the Kim andKratchman classification (5)
Intact coronal restorations with no evidence of leakage or caries under therestoration.

Exclusion

Exclusion Criteria:

Minors.
Suspected root fractures.
ASA classification 3 or greater.
Periapical pathology Class D, E, or F according to the Kim and Kratchmanclassification (5).
Patients with history of Oral or IV Bisphosphonate use.
Patients may be excluded if their treatment team do not believe Endodonticmicrosurgery and L-PRF graft is in the patient's best interests.

Study Design