Combined THC and CBD for OUD and Chronic Pain

Inclusion Criteria:

1. Provision of signed and dated informed consent form.

2. Stated willingness to comply with all study procedures and availability for theduration of the study.

3. Male or female aged 18-65 years.

4. Co-occurring OUD (meeting DSM-5 criteria) and chronic pain (uniformlyoperationalized as high-impact [occurring most days, limiting life or workactivities] non-cancer low back pain for ≥ 3 months).

5. Prior exposure to cannabis or its constituent cannabinoids at least once in the last 10 years, 1-10 times in the last 20 years, or more than 20 times in lifetime.

6. Adherence to their clinically prescribed methadone therapy, on a stable dose (30-150mg/day ≥ 3 weeks).

7. For females of reproductive potential: use of highly effective contraception for atleast 1 month prior to screening and agreement to use such a method during studyparticipation and for an additional 2 weeks after the last test session.

8. For males of reproductive potential: use of condoms or other methods to ensureeffective contraception with partner.

Exclusion Criteria:

1. Meeting DSM-5 criteria for cannabis use disorder and/or substance use disorders (SUDs) other than OUD or tobacco use disorder, within the last 12 months.

2. Clinically significant medical disorders as noted by the participant or throughstudy screening procedures (e.g. liver dysfunction, as indicated by ALT and/or AST > 1.5 times the normal limit).

3. Neurological conditions that may change the response to nociceptive stimuli (e.g.,stroke, neuropathy), or that lead to loss of balance, evidenced by a neuro-sensoryexam during screening.

4. Contraindications for exposure to nociceptive stimuli, such as untreatedhypertension, verbally noted by participant or verified during screening procedures.

5. Abnormal screening EKG (QTc interval >450 ms), arrythmia, or vasospastic disease.

6. Positive urine pregnancy test, or lack of birth control measures in women ofchildbearing potential. For males of reproductive potential refusal to use condomsor other methods to ensure effective contraception with partner.

7. Currently lactating.

8. Male participants who plan to donate sperm starting at screening and through 90 daysafter final study drug administration.

9. Females who plan to donate ova starting at screening through 28 days after finalstudy drug administration.

10. History of primary psychotic disorders or mood disorders with psychotic features.

11. Current suicidal ideation or related behavior.

12. A physician will carefully evaluate participants for use of over-the-counter orprescription psychoactive drugs known to affect pain threshold or pain tolerance (including NSAIDS, serotonin-norepinephrine reuptake inhibitors (SNRIs) (e.g.venlafaxine, duloxetine), gabapentinoids, tricyclic antidepressants (e.g.,nortriptyline, amitriptyline), anticonvulsant medications (e.g., topiramate,carbamazepine). Only participants who are on stable doses (i.e., consistent dailyadministration of the medication for at least three months at the same dosefollowing the last dose change, either increase or decrease) of these medications,and whose dosing schedules allow participation in the study visits, thus excludinginstances of single-dose or temporary dosing of the medication, will be eligible asdetermined by the sponsor-investigator. If possible, the morning dose will beadministered after the study visit.

13. Current, regular use of benzodiazepines, other prescription opioids, or plateletinhibitors (e.g., clopidogrel, apixaban, ticagrelor).

14. Allergy or serious adverse reaction to cannabis or its constituent cannabinoid.

15. Allergy or serious adverse reaction to sesame oil or seeds.

16. Allergy or serious adverse reaction to Butylated Hydroxytoluene (BHT).

17. Unable to swallow or have difficulty swallowing capsules.

18. Prior to receiving the study medication on the first test session, participants'cannabinoid use will be assessed using a quantitative point-of-care urine 11-nor-9-carboxy-THC concentration test with a cut-off of ≤ 50 mg/mL. If aparticipant tests greater than ≤ 50 mg/mL, they will be asked to abstain for anadditional 7 to 14 days. If 14 days after their initial THC concentration test theparticipant continues to test positive, they will not be allowed to participate inthe study.