A Study to Evaluate Safety, PK, PD and Efficacy of AZD5492, a T Cell-engaging Antibody Targeting CD20 in Subjects With R/R B-Cell Malignancies.

Inclusion Criteria:

• ≥18 years of age;

• Histologically documented CD20+ mature B-cell neoplasm

• Large B-cell lymphoma

• Follicular lymphoma

• Mantle cell lymphoma

• Chronic lymphocytic leukemia

• Small lymphocytic lymphoma

• Relapsed, progressive and/or refractory disease following at least 2 prior lines oftherapy;

• ECOG performance status of ≤ 2 (< 2 in EU countries).

The above is a summary, other inclusion criteria details may apply.

Exclusion Criteria:

• Any neoplasm histology not specified in the IC section;

• Active CNS involvement in lymphoma;

• CNS pathology including but not limited to any history of seizure disorder/epilepsy;

• Prior allogeneic HSCT within 180 days, prior autologous HSCT within 90 days, or celltherapy within 90 days of start of therapy;

• History of Grade ≥ 3 CRS or Grade ≥ 3 ICANS;

• Active and uncontrolled infections;

• Unresolved AEs ≥2 Grade due to prior anticancer therapies, with some exceptions

The above is a summary, other exclusion criteria details may apply.