Mannitol-induced Release of Copeptin in Healthy Adults and Patients With Polyuria-Polydipsia Syndrome (MARS Study)

Inclusion Criteria:

Part 1: Proof of Concept in Healthy adults

• Age ≥ 18 years

• Healthy with no medication except hormonal contraception

Part 2: Pilot Study in Patients with primary polydipsia (PP) or arginine vasopressin deficiency (AVP-D)

• Age ≥ 18 years

• Evidence of polyuria > 40-50 ml/kg body weight per 24 hours and polydipsia > 3 Literper 24 hours or regular desmopressin medication corresponding to a diagnosis of PPor AVP-D

Exclusion Criteria:

Part 1: Proof of Concept in Healthy adults

• Participation in a trial with investigational drugs within 30 days

• Evidence of disordered drinking habits and diuresis defined as polyuria > 40-50ml/kg body weight per 24 hours and polydipsia > 3 Liter per 24 hours.

• Estimated Glomerular Filtration Rate (eGFR) < 60 ml/min/1,73 m2

• Glucose > 11.1 mmol/L corresponding to the diagnosis of an uncontrolled diabetesmellitus

• History of urinary tract obstruction

• Problems with urination

• Pregnancy or breastfeeding

• Multiple allergies (≥ 3)

• Evidence of acute illness

Part 2: Pilot Study in Patients with PP or AVP-D

• Participation in a trial with investigational drugs within 30 days

• Pregnancy or breastfeeding

• Evidence of acute illness

• eGFR < 60 ml/min/1,73 m2

• Glucose > 11.1 mmol/L corresponding to the diagnosis of uncontrolled diabetesmellitus

• History of urinary tract obstruction

• Problems with urination

• Therapy with diuretics

• Multiple allergies (≥ 3)