Effect of Statins on Crohn's Disease

Inclusion Criteria:

1. Established diagnosis of stricturing Crohn's disease

2. Scheduled for surgical resection of terminal ileum strictures at either

• Stanford University, or

• Dr. Phillip Fleshner's colorectal surgery practice in Los Angeles

Exclusion Criteria:

1. Pregnant, nursing, or planning to become pregnant in the next 6-12 months

2. Severe renal dysfunction (stage 5 chronic kidney disease (CKD), end-stage renaldisease (ESRD))

3. Known clinical allergy or prior adverse reaction to statin therapy (e.g.,rhabdomyolysis)

4. Current use of cyclosporine

5. Current use of statin therapy prior to study initiation

6. Clinical diagnosis of active liver disease (beyond metabolic dysfunction-associatedsteatotic liver disease (MASLD)) with unexplained persistent elevations in hepatictransaminase levels

7. Current use of any of the following medications, without explicit clearance from atreating physician to enroll in the study:

• Antifungals (e.g., ketoconazole, itraconazole, voriconazole)

• Fibrate drugs

• Macrolide antibiotics (e.g., erythromycin, clarithromycin)

• Protease inhibitors (e.g., ritonavir, lopinavir)

• Calcium channel blockers (e.g., verapamil, diltiazem)

• Amiodarone

• Warfarin

• Colchicine