Greens-Based Crossover Trial to Improve Epigenetic Aging in Adults

Last updated: January 7, 2025
Sponsor: Auburn University
Overall Status: Active - Not Recruiting

Phase

N/A

Condition

Aging

Treatment

Greens-based Supplement

Clinical Study ID

NCT06537232
AUBHG 24
  • Ages 50-65
  • All Genders
  • Accepts Healthy Volunteers

Study Summary

The primary purpose of this study is to assess changes in epigenetic markers of aging and physiological parameters in overweight older adults consuming a mixed greens-based supplement over a 30-day period in a randomized crossover design.

Eligibility Criteria

Inclusion

Inclusion Criteria:

  • Men and women of any ethnicity (women must be postmenopausal)

  • Body Mass Index > 30 kg/m^2

  • Low habitual dark green leafy vegetable consumption

  • Willing to adhere to study protocol and measures

  • Willing to communicate via smartphone technology

  • Able to read, write and speak English

Exclusion

Exclusion Criteria:

  • Overt cardiometabolic diseases such heart attack, stroke, diabetes, insulinresistance and non-alcoholic fatty liver disease, etc.

  • Diagnosis of a transient ischemic attack in the 6 months prior to screening

  • Diagnosis of cancer within 5 years prior to screening, except for cutaneous basalcell or squamous cell cancer resolved by excision

  • Food allergies

Study Design

Total Participants: 20
Treatment Group(s): 1
Primary Treatment: Greens-based Supplement
Phase:
Study Start date:
September 04, 2024
Estimated Completion Date:
March 31, 2025

Study Description

Investigators will recruit 20 overweight/obese but otherwise healthy participants aged 50-65. Participants will be randomized to consume the greens-based supplement each morning for the first 30 days or second 30 days of the study. Usual diet, physical activity, and sleep patterns will be encouraged and monitored during the duration of the study.

Phlebotomy will be conducted at baseline, 30-day crossover, and 60-day follow-up to assess DNA methylation in peripheral blood mononuclear cells. Visceral and total body fat, stool microbiome composition, and actigraphy will also be assessed.

Connect with a study center

  • Auburn University

    Auburn, Alabama 36849
    United States

    Site Not Available

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