Individualized Exercise Combined With Manual Therapy in Severe Hemophilia Patients With Polyarthropathy

Last updated: March 1, 2025
Sponsor: Far Eastern Memorial Hospital
Overall Status: Active - Recruiting

Phase

N/A

Condition

Hemophilia

Treatment

Manual therapy combined exercise

Clinical Study ID

NCT06535971
111296-E
FarEasternMH
  • Ages > 20
  • All Genders

Study Summary

The aim of this study is to investigate the effect of individualized physical therapy, combined manual therapy and exercise intervention, for pain perception, range of motion (ROM), muscle strength, joint health, cardiopulmonary endurance and quality of life (QoL) in patients with severe hemophilia A and multiple hemophilic arthropathy.

Eligibility Criteria

Inclusion

Inclusion Criteria:

  • over 20 years old and diagnosed with severe hemophilia

  • those who receive prophylaxis regularly

  • there are more than 2 target joints (hemophilic arthropathy)

Exclusion

Exclusion Criteria:

  • unwilling to sign the informed consent

  • any neurological disease or specific musculoskeletal condition (such as fracture)one year ago

  • more than 3 (excluding 3) joint replacement surgeries (different joints)

  • unable to walk due to hemophilia joint disease or any other diseases

  • major bleeding events that pose risks or hinder research

  • unable to follow instructions due to cognitive impairment

Study Design

Total Participants: 10
Treatment Group(s): 1
Primary Treatment: Manual therapy combined exercise
Phase:
Study Start date:
July 05, 2024
Estimated Completion Date:
December 31, 2025

Study Description

The main clinical manifestations of hemophilia are muscle and joint bleeding. Recurrent bleeding leads to a degenerative process known as hemophilic arthropathy. Past studies investigated the effect of manual therapy of exercise for individuals with hemophilia and found to enhance muscle strength, balance, fitness and promote quality of life. However, less study has evaluated the safety and effectiveness of manual therapy combined with exercise for individuals with multiple hemophilic arthropathy. Therefore, the aim of this study is to investigate the effect of individualized physical therapy, combined manual therapy and exercise intervention, for pain perception, range of motion (ROM), muscle strength, joint health, cardiopulmonary endurance and quality of life (QoL) in patients with severe hemophilia A and multiple hemophilic arthropathy.

Connect with a study center

  • Far Eastern Memorial hospital

    New Taipei City, 220
    Taiwan

    Active - Recruiting

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