Study on Multimodal Imaging and Molecular Imaging Techniques in Degenerative Dementia

Inclusion Criteria:

• Patients aged ≥50 and ≤85 years old, male or female;

• Meet the diagnostic criteria for dementia or MCI;

• Neuropsychological score: MMSE 15-28 points, CDR ≤ 1 point; ④ Patients and theirfamilies are informed and sign the informed consent form

Exclusion Criteria:

• The presence of other neurological diseases that may cause brain dysfunction (suchas depression, brain tumors, Parkinson's disease, metabolic encephalopathy,encephalitis, multiple sclerosis, epilepsy, brain trauma, normal intracranialpressure hydrocephalus, etc.);

• The presence of other systemic diseases that may cause cognitive impairment (such asliver dysfunction, renal dysfunction, thyroid dysfunction, severe anemia, folic acidor vitamin B12 deficiency, syphilis, HIV infection, alcohol and drug abuse, etc.);

• Suffering from a disease that makes it impossible to cooperate with cognitiveexaminations;

• The presence of contraindications to MRI;

• The presence of mental and neurological retardation;

• Refusing to draw blood;

• Refusing to sign the informed consent form.