A Study Evaluating Multiple Ascending Doses of QRL-101 in Healthy Participants

Inclusion Criteria:

1. Age 18 to 70 years of age inclusive at the time of signing the informed consent.

2. Clinical chemistry laboratory values within acceptable range for the population, asper investigator judgment.

3. Body mass index of 18 to 32 kg/m2 (inclusive).

4. Willing and able to practice effective contraception.

Exclusion Criteria:

1. Currently enrolled in any other clinical trial involving a study drug or off-labeluse of a drug or device, or any other type of medical research judged not to bescientifically or medically compatible with this study.

2. Any participant in >4 studies a year and/or has participated in a clinical trialwithin 1 month of expected dosing date.

3. History or presence of medical illness including, but not limited to, anycardiovascular, hepatic, respiratory, hematological, endocrine, psychiatric, orneurological disease, convulsions, or any clinically significant laboratoryabnormality that, in the judgment of the investigator, indicate a medical problemthat would preclude study participation.