Michigan Split-belt Treadmill Training Program to Improve Acute Knee Biomechanics After ACL Reconstruction

Last updated: October 29, 2024
Sponsor: University of Michigan
Overall Status: Active - Recruiting

Phase

N/A

Condition

N/A

Treatment

Tied-Belt Training

Split-belt Training

Clinical Study ID

NCT06529679
HUM00221406_Aim2
1R21AR082643
  • Ages 14-45
  • All Genders

Study Summary

The goal of this study is to determine short-term adaptations (aftereffects) in knee loading after a 20-minute split-belt treadmill training session in patients with ACL reconstruction.

Our main question for this aim are:

  1. Are training-mediated aftereffects in the knee joint moment greater for tied-belt walking or split-belt walking?

  2. Are training-mediated aftereffects in the knee joint moment different between subjects who train early stance knee loading versus subjects who train mid-stance knee loading?

Eligibility Criteria

Inclusion

Inclusion Criteria:

  • aged 14-45 years

  • suffered an acute, complete ACL rupture as confirmed by MRI and physical exam

  • have undergone ACL reconstruction w autograft within the past 10 months

  • willingness to participate in testing and follow-up as outlined in the protocol

  • English-speaking

Exclusion

Exclusion Criteria:

  • inability to provide written informed consent

  • female subjects who are pregnant or are planning to become pregnant (self-reported)

  • previous ACL injury

  • previous surgery to either knee

  • bony fracture accompanying ACL injury

  • patients who experienced a knee dislocation

  • patients who had their ACL reconstructed with an allograft

  • patients who underwent a multi-ligamentous and/or staged ACL reconstruction

Study Design

Total Participants: 30
Treatment Group(s): 2
Primary Treatment: Tied-Belt Training
Phase:
Study Start date:
October 29, 2024
Estimated Completion Date:
December 31, 2025

Study Description

Knee and limb underloading are ubiquitous after anterior cruciate ligament (ACL) reconstruction and fails to resolve with the standard of care rehabilitation. This underloading behavior is clinically concerning and considered maladaptive, as it affects patient function, has been linked to risk for re-injury, and appears to be a precursor for post-traumatic knee osteoarthritis that affects upwards of 50% of patients who undergo an ACL reconstruction.

Split-belt treadmill training is a gait retraining approach where treadmill belt speeds are decoupled (i.e., one belt is set to move at a faster or slower speed than the other belt) during walking. Split-belt training is based on well-established motor learning principles, such as error-based learning and variability of practice which can lead to locomotor adaptations. In healthy individuals, split-belt treadmill walking significantly increases knee moment impulses in the limb on the slow belt than on the fast belt during the braking and propulsive phases of gait. Split-belt treadmill training has also shown promise in individuals with neurological deficits, resulting in significant improvements in gait biomechanics after training.

The aim of this project is to determine short-term adaptations (aftereffects) in knee loading after a 20-minute split-belt treadmill training session in individuals with anterior cruciate ligament (ACL) reconstruction. Individuals ~6-10 months after ACL reconstruction will be randomly assigned to 1 of 2 groups and each group will complete a split-belt and tied-belt session. One group will train the early stance knee moment with split-belt walking, while the other group will train the mid-stance knee moment with split-belt walking. Both groups will also complete a tied-belt session. Bilateral knee loading will be quantified using peak knee moments before training (10 min), during training (20 min), and after training (10 min). The investigators hypothesize that the training-mediated aftereffects (i.e., loading after training) will be significantly higher in the split-belt condition than in the tied-belt control condition. The investigators also hypothesize that early stance split-belt training will lead to training-mediated aftereffects for the early stance moment only, while mid-stance training will only result in aftereffects for the mid-stance knee moment.

Connect with a study center

  • University of Michigan

    Ann Arbor, Michigan 48109
    United States

    Active - Recruiting

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