A Study of CT-388 in Participants with Obesity or Overweight with At Least One Weight-Related Comorbidity

Inclusion Criteria:

• Male or female, 18 to 75 years of age

• Body mass index (BMI) ≥30.0 kg/m2, OR BMI ≥27.0 and <30.0 kg/m2 and previouslydiagnosed with at least 1 of the following weight-related comorbidities, such as:prediabetes, hypertension, dyslipidemia, obstructive sleep apnea, or cardiovasculardisease

• At least one self-reported unsuccessful effort to lose body weight

Exclusion Criteria:

• Prior history/diagnosis/lab evidence of any type of diabetes mellitus (e.g., Type 1,Type 2, gestational), or a history of ketoacidosis or hyperosmolar state

• Self-reported body weight change of >5 kg within 3 months before randomization

• Any unbalanced/extreme diets within 3 months of the screening visit, or plan to beon such diets during the study

• Current or recent participation in an organized weight reduction program

• Current or recent use of any treatment that promotes weight loss or glucosemetabolism

• Current or recent use of treatment that may cause weight gain

• Prior or planned surgical treatment for obesity

• Clinically significant or active gastric emptying abnormality, malabsorption, orchronic use of medications that directly affect GI motility

• History of chronic pancreatitis or acute pancreatitis within 6 months beforescreening

• Have obesity induced by other endocrinologic disorders (e.g., Cushing syndrome) ordiagnosed monogenetic or syndromic forms of obesity

• History of major depressive disorder within 2 years of screening, or anyhistory/diagnosis of other severe psychiatric conditions (Note: Prospectiveparticipants with depression or anxiety whose disease state, in the opinion of theInvestigator, is considered stable and expected to remain stable throughout thecourse of the study, may be considered for inclusion)

• Family or personal history of medullary thyroid carcinoma

• Serum calcitonin ≥ 20 ng/L

• Women who are pregnant, breastfeeding, or intend to become pregnant, or are ofchildbearing potential and not using a highly effective contraceptive method