Olanzapine for Cancer Related Anorexia-cachexia Syndrome

Inclusion Criteria:

• pathologically or cytologically metastatic or locally advanced cancer

• anorexia and >=5% weight loss during the past 6 months or anorexia with numericalscale of anorexia >=5

• ECOG performance status 0-3

• able to complete questionaire and able to swallow pills

Exclusion Criteria:

• receiving chemotherapy or anti-cancer systemic therapy

• life expectancy longer than 1 month

• received radiotherapy at head/neck or thoracic or upper abdomen in the past 2 weeks

• surgery within 4 weeks

• pregnancy

• serum bilirubin > 2 mg/dl or serum Cr > 2 mg/dl

• current use of olanzapine or other antipsychotic drug

• known cardiac arrhythmia, uncontrolled brain metastasis, history of seizure or acutecoronary event in the past 6 months