tDCS for Post-Stroke Cognitive Impairment

Last updated: October 8, 2024
Sponsor: University of Oklahoma
Overall Status: Active - Recruiting

Phase

2

Condition

Cerebral Ischemia

Memory Problems

Alzheimer's Disease

Treatment

Transcranial Dirrect Current Stimulation

Clinical Study ID

NCT06516588
17265
  • Ages 18-99
  • All Genders

Study Summary

This study will evaluate the effects of a form of non-invasive brain stimulation on brain functioning and memory in participants with post-stroke cognitive impairment (PSCI).

Eligibility Criteria

Inclusion

Inclusion Criteria:

  1. ischemic stroke participants in sub-acute phase (at least 10 days after stroke eventor discharge and under 5 months post-event) with cognitive dysfunction (MoCA <26);

Exclusion

Exclusion Criteria:

  1. clinically significant or unstable medical or psychiatric condition;

  2. diagnosis of severe depression;

  3. history of relevant neurological diagnosis (e.g., epilepsy);

  4. previous neurosurgical procedure with craniectomy;

  5. contraindications to tDCS (implanted brain medical devices);

  6. severe visual impairment, hearing impairment, aphasia, neglect or dementia.

Study Design

Total Participants: 80
Treatment Group(s): 1
Primary Treatment: Transcranial Dirrect Current Stimulation
Phase: 2
Study Start date:
September 30, 2024
Estimated Completion Date:
June 30, 2027

Study Description

The goal of this study is to learn important information about the effects of electrical stimulation (Transcranial direct current stimulation (tDCS) on brain functioning in those with post-stroke cognitive impairment (PSCI). The findings will help determine how stimulation affects the brain's activity, cerebral blood flow, and circulating blood biomarkers of neuroinflammation after stroke. The study will use different forms of non-invasive brain imaging to see whether stimulation changes how the brain responds during a memory task. Functional near-infrared spectroscopy (fNIRS) and electroencephalograph (EEG) will be used, we will also collect blood samples for the biomarkers of inflammation. The study also uses cognitive tests and questionnaires.

Connect with a study center

  • University of Oklahoma

    Oklahoma City, Oklahoma 73117
    United States

    Active - Recruiting

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