The Application of Different Sedation Protocols in ICU Patients With Severe Pneumonia

Last updated: July 17, 2024
Sponsor: Xiangya Hospital of Central South University
Overall Status: Active - Recruiting

Phase

N/A

Condition

Pneumonia

Treatment

N/A

Clinical Study ID

NCT06514781
2024020151
  • Ages > 18
  • All Genders

Study Summary

This study collected data from 600 patients with severe pneumonia to compare the duration of mechanical ventilation under different sedation regimens in real-world settings. It also evaluated and compared the sedation success rates, hemodynamic changes, and clinical outcomes of patients with severe pneumonia.

Eligibility Criteria

Inclusion

Inclusion Criteria:

(1)From February 1, 2023, to March 30, 2024, diagnosed with severe pneumonia in the Respiratory Intensive Care Unit of Xiangya Hospital, Central South University. The diagnosis of severe pneumonia is based on meeting at least one major criterion or three or more minor criteria:

  1. Major criteria:

①Infectious shock requiring vasopressor therapy despite adequate fluidresuscitation;②Respiratory failure requiring tracheal intubation or mechanicalventilation.

  1. Minor criteria:
  • Respiratory rate ≥ 30 breaths/min; ②Oxygenation index (PaO2/FiO2) ≤ 250;
  • Involvement of multiple lobes; ④Altered mental status and/ordisorientation; ⑤Blood urea nitrogen ≥ 20 mg/dl (7.14 mmol/L); ⑥Systolicblood pressure < 90 mmHg requiring aggressive fluid resuscitation. (2)Patients receiving mechanical ventilation who require sedationtreatment. (3)Age ≥ 18 years.

Exclusion

Exclusion Criteria:

  1. Allergic to routine sedative or analgesic medications.

  2. Patients who have not undergone pain and sedation assessment.

  3. Patients transferred to another hospital during treatment.

  4. Patients who abandon treatment and are discharged within less than 72 hours oftreatment.

Study Design

Total Participants: 600
Study Start date:
January 01, 2024
Estimated Completion Date:
December 31, 2024

Study Description

The study subjects were patients with severe pneumonia hospitalized in the Department of Respiratory and Critical Care Medicine at Xiangya Hospital, Central South University, from January 2024 to December 2024. Patients meeting all the following criteria were enrolled: (1) diagnosed with severe pneumonia; (2) receiving mechanical ventilation and requiring sedation treatment; (3) age ≥ 18 years. Patients were excluded if they met any of the following conditions: (1) allergic to routine sedative or analgesic medications; (2) had not undergone pain and sedation assessment; (3) transferred to another hospital during treatment; (4) abandoned treatment and were discharged within <72 hours of treatment. Data on patient demographics, laboratory tests, chest imaging, respiratory support methods, severity of illness assessments, sedative medication usage, and clinical outcomes were collected. The duration of mechanical ventilation under different sedation regimens in real-world settings was compared, and the correlation between sedation success rates, hemodynamic changes, and clinical outcomes in patients with severe pneumonia was evaluated and compared.

Connect with a study center

  • Xiangya Hospital Central South University

    Changsha, Hunan 410008
    China

    Active - Recruiting

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