A Trial of Chinese Traditional Medicine Combining With Intradermal Acupuncture for Treating Precocious Puberty

Inclusion Criteria:

• Girls are diagnosed as Idiopathic precocious puberty, and their age of onset ≤7.5years;

• Tanner stages of breast in female patients ≤ Tanner III stage, diameters ofmammillary nucleus ≤ 3cm; •B-type ultrasonography: the volume of uterus≥ 3ml, thevolume of ovary≥1.5ml, the diameter of follicle≥4mm;

• Bone age: compared the chronological age, the bone age is less than 1 year and thebone age <10 years old;

• No GnRH analogs or Sex hormones were administrated in the past; and All above areneeded at the same time.

Exclusion Criteria:

• Precocity caused by the central nervous system organic diseases;

• Precocious precocity caused by congenital hypothyroidism, congenital adrenalhyperplasia, adrenal tumor and ovarian or testicular neoplasms as well asMcCune-Albright syndrome, etc;

• Precocious precocity with a family history of diseases such as tumor, leukemia,diabetes, systemic lupus erythematous;

• Pseudo sexual precocity and partial precocious puberty.