Phase
Condition
Lymphoma, B-cell
Lymphoma
Hematologic Cancer
Treatment
Lenalidomide
Epcoritamab
Gemcitabine
Clinical Study ID
Ages > 18 All Genders
Study Summary
Eligibility Criteria
Inclusion
Inclusion Criteria:
Eastern Cooperative Oncology Group Performance status score of 0 to 2.
Histologically confirmed CD20+ Diffuse Large B-Cell Lymphoma (DLBCL) and documentedin the most recent and representative pathology report, inclusive of the followingaccording to the World Health Organization (WHO) 2022 as per the protocol.
Must have relapsed or refractory (R/R) disease and have been previously treated withat least 1 line of systemic antineoplastic therapy including anti-CD20mAb-containing combination chemotherapy since DLBCL diagnosis.
. Participant must meet at least 1 of the following criteria:
Failed prior autologous stem cell transplant (ASCT), defined as relapsed afterASCT or been refractory to ASCT.
Not be considered a candidate for ASCT due to age, performance status,comorbidities and/or insufficient response to prior treatment, or have refusedASCT.
Be ineligible for or unable to receive chimeric antigen receptor T-cell (CAR-T)meeting at least 1 of the following criteria:
Unable to receive CAR-T therapy due to fitness and/or comorbidity.
Lymphocyte apheresis failure.
Unwilling to receive CAR-T therapy.
Unable to receive CAR-T therapy due to financial, geographic, insurance,access, and/or manufacturing constraints.
Relapsed/progressed after having achieved at least a Partial Response (PR)or Complete Response (CR) while on prior CAR-T therapy.
Must have measurable disease.
Life expectancy > 3 months on standard of care treatment at the time of enrolling inthe study
Exclusion
Exclusion Criteria:
Current evidence of primary central nervous system (CNS) lymphoma or known CNSinvolvement by lymphoma including leptomeningeal disease, at screening.
History of prior treatment with a bispecific antibody targeting CD3 and CD20 orprior treatment with rituximab plus gemcitabine and oxaliplatin (R-GemOx) orgemcitabine and oxaliplatin (GemOx).
Documented refractoriness to lenalidomide.
Study Design
Connect with a study center
Canberra Hospital /ID# 265312
Canberra, Australian Capital Territory 2605
AustraliaActive - Recruiting
Royal Prince Alfred Hospital /ID# 263242
Sydney, New South Wales 2050
AustraliaActive - Recruiting
Wollongong Hospital /ID# 244646
Wollongong, New South Wales 2500
AustraliaActive - Recruiting
Toowoomba Hospital /ID# 263243
Toowoomba, Queensland 4350
AustraliaActive - Recruiting
Monash Health - Monash Medical Centre /ID# 262783
Clayton, Victoria 3168
AustraliaActive - Recruiting
Monash Medical Centre /ID# 262783
Clayton, Victoria 3168
AustraliaActive - Recruiting
Royal Perth Hospital /ID# 243790
Perth, Western Australia 6000
AustraliaActive - Recruiting
Universitair Ziekenhuis Brussel /ID# 242574
Jette, Bruxelles-Capitale 1090
BelgiumActive - Recruiting
Centre Hospitalier Epicura - site d'Hornu /ID# 265148
Boussu, Hainaut 7301
BelgiumActive - Recruiting
Université Catholique de Louvain-Namur - Centre Hospitalier Universitaire Dinant /ID# 242565
Yvoir, Namur 5530
BelgiumActive - Recruiting
Universitair Ziekenhuis Leuven /ID# 246671
Leuven, Vlaams-Brabant 3000
BelgiumActive - Recruiting
AZ-Delta /ID# 264740
Roeselare, West-Vlaanderen 8800
BelgiumActive - Recruiting
UMHAT Sveti Georgi /ID# 242905
Plovdiv, 4002
BulgariaActive - Recruiting
SHAT Hematologic Diseases /ID# 242708
Sofia, 1797
BulgariaActive - Recruiting
UMHAT Sveti Ivan Rilski /ID# 242389
Sofia, 1431
BulgariaActive - Recruiting
UMHAT Sveta Marina /ID# 262761
Varna, 9010
BulgariaActive - Recruiting
Peking University Third Hospital /ID# 242941
Beijing, Beijing 100191
ChinaActive - Recruiting
Guangdong Provincial People's Hospital /ID# 242942
Guangzhou, Guangdong 510080
ChinaActive - Recruiting
Sun Yat-Sen University Cancer Center /ID# 242712
Guangzhou, Guangdong 510060
ChinaActive - Recruiting
The Second Hospital of Hebei Medical University /ID# 242944
Shijiazhuang, Hebei 050000
ChinaActive - Recruiting
Hubei Cancer Hospital /ID# 242963
Wuhan, Hubei 430079
ChinaActive - Recruiting
Union Hospital affiliated to Tongji Medical College of Huazhong University of Sc /ID# 242702
Wuhan, Hubei 430022
ChinaActive - Recruiting
The First Affiliated Hospital of Soochow University /ID# 242939
Suzhou, Jiangsu 215006
ChinaActive - Recruiting
The First Hospital of Jilin University /ID# 242940
Changchun, Jilin 130021
ChinaActive - Recruiting
Shandong Cancer Hospital /ID# 264036
Jinan, Shandong 250117
ChinaActive - Recruiting
Institute of Hematology & Blood Diseases Hospital, Chinese Academy of Medical Sc /ID# 243139
Tianjin, Tianjin 300020
ChinaActive - Recruiting
Tianjin Cancer Hospital /ID# 243940
Tianjin, Tianjin 300000
ChinaActive - Recruiting
The Affiliated Cancer Hospital of Xinjiang Medical University /ID# 242966
Urumqi, Xinjiang 830000
ChinaActive - Recruiting
The second affiliated hospital of Zhejiang University school of medicine /ID# 243137
Hangzhou, Zhejiang 310009
ChinaActive - Recruiting
The First Affiliated Hospital of Wenzhou Medical University /ID# 263951
Wenzhou, Zhejiang 325000
ChinaActive - Recruiting
Klinicka bolnica Merkur /ID# 262619
Zagreb, Grad Zagreb 10000
CroatiaActive - Recruiting
Klinicki bolnicki centar Sestre milosrdnice /ID# 262620
Zagreb, Grad Zagreb 10000
CroatiaActive - Recruiting
Klinicki bolnicki centar Zagreb /ID# 262617
Zagreb, Grad Zagreb 10000
CroatiaActive - Recruiting
Klinicki bolnicki centar Osijek /ID# 262621
Osijek, Osjecko-baranjska Zupanija 31000
CroatiaActive - Recruiting
Klinički Bolnički Centar Rijeka /ID# 266004
Rijeka, Primorsko-goranska Zupanija 51000
CroatiaActive - Recruiting
Klinicki Bolnicki Centar (KBC) Split /ID# 262618
Split, Splitsko-dalmatinska Zupanija 21000
CroatiaActive - Recruiting
Fakultní nemocnice Hradec Králové - Sokolská /ID# 264071
Hradec Králové, Hradec Kralove 500 05
CzechiaActive - Recruiting
CHRU Tours - Hopital Bretonneau /ID# 244580
Tours CEDEX 9, Indre-et-Loire 37044
FranceActive - Recruiting
Centre Hospitalier D'Avignon /ID# 243072
Avignon, Provence-Alpes-Cote-d Azur 84000
FranceActive - Recruiting
Centre Hospitalier de la Cote Basque /ID# 243065
Bayonne, Pyrenees-Atlantiques 64100
FranceActive - Recruiting
CHU Poitiers - La miletrie /ID# 243074
Poitiers, Vienne 86000
FranceActive - Recruiting
CHU de CAEN - Hopital de la Cote de Nacre /ID# 243075
Caen, 14033
FranceActive - Recruiting
Hopital Saint Vincent de Paul /ID# 243070
Lille Cedex, 59020
FranceActive - Recruiting
Institut de cancérologie Strasbourg Europe (ICANS) /ID# 264068
Strasbourg, 67200
FranceActive - Recruiting
General Hospital of Athens Laiko /ID# 262809
Athens, Attiki 11527
GreeceActive - Recruiting
University General Hospital Attikon /ID# 242041
Athens, Attiki 12462
GreeceActive - Recruiting
General Hospital of Athens Evaggelismos and Ophthalmiatrio of Athens Polyclinic /ID# 242039
Athens, 10676
GreeceActive - Recruiting
General University Hospital of Thessaloniki AXEPA /ID# 242038
Thessaloniki, 54636
GreeceActive - Recruiting
Theageneio Anticancer Hospital /ID# 242036
Thessaloniki, 54639
GreeceActive - Recruiting
Pecsi Tudomanyegyetem Klinikai Kozpont /ID# 262924
Pecs, Baranya 7624
HungaryActive - Recruiting
Gyor-Moson-Sopron Varmegyei Petz Aladar Egyetemi Oktato Korhaz /ID# 262901
Gyor, Gyor-Moson-Sopron 9024
HungaryActive - Recruiting
Debreceni Egyetem-Klinikai Kozpont /ID# 242451
Debrecen, Hajdu-Bihar 4032
HungaryActive - Recruiting
Szabolcs-Szatmar-Bereg Varmegyei Oktatokorhaz /ID# 242468
Nyiregyhaza, Szabolcs-Szatmar-Bereg 4400
HungaryActive - Recruiting
Del-pesti Centrumkorhaz Orszagos Hematologiai es Infektologiai Intezet /ID# 262923
Budapest, 1097
HungaryActive - Recruiting
Orszagos Onkologiai Intezet /ID# 242457
Budapest, 1122
HungaryActive - Recruiting
Semmelweis Egyetem /ID# 242455
Budapest, 1085
HungaryActive - Recruiting
Fujita Health University Hospital /ID# 265968
Toyoake, Aichi 470-1192
JapanActive - Recruiting
National Hospital Organization Shikoku Cancer Center /ID# 265977
Matsuyama, Ehime 791-0280
JapanActive - Recruiting
Kyushu University Hospital /ID# 267624
Fukuoka-shi, Fukuoka 812-8582
JapanActive - Recruiting
Fukushima Medical University Hospital /ID# 264667
Fukushima-shi, Fukushima 960-1295
JapanActive - Recruiting
Sapporo Medical University Hospital /ID# 264928
Sapporo, Hokkaido 060-8543
JapanActive - Recruiting
Kagoshima University Hospital /ID# 248259
Kagoshima-shi, Kagoshima 890-8520
JapanActive - Recruiting
Tokai University Hospital /ID# 265433
Isehara, Kanagawa 259-1193
JapanActive - Recruiting
Kansai Medical University Hospital /ID# 266018
Hirakata-shi, Osaka 573-1191
JapanActive - Recruiting
Kindai University Hospital /ID# 265474
Osakasayama-shi, Osaka 589-8511
JapanActive - Recruiting
Saitama Cancer Center /ID# 265277
Kitaadachi-gun, Saitama 362-0806
JapanActive - Recruiting
University of Yamanashi Hospital /ID# 264671
Chuo, Yamanashi 409-3898
JapanActive - Recruiting
Dong-A University Medical Center /ID# 262841
Busan, Busan Gwang Yeogsi 49201
Korea, Republic ofActive - Recruiting
Inje University - Busan Paik Hospital /ID# 262842
Busan, Busan Gwang Yeogsi 47392
Korea, Republic ofActive - Recruiting
Seoul National University Bundang Hospital /ID# 242405
Seongnam-si, Gyeonggido 13620
Korea, Republic ofActive - Recruiting
Keimyung University Dongsan Hospital /ID# 262840
Daegu, Gyeongsangbugdo 42601
Korea, Republic ofActive - Recruiting
Jeonbuk National University Hospital /ID# 242958
Jeonju, Jeonrabugdo 54907
Korea, Republic ofActive - Recruiting
Chonnam National University Hwasun Hospital /ID# 262843
Hwasun-gun, Jeonranamdo 58128
Korea, Republic ofActive - Recruiting
Asan Medical Center /ID# 242409
Seoul, Seoul Teugbyeolsi 05505
Korea, Republic ofActive - Recruiting
Samsung Medical Center /ID# 242408
Seoul, Seoul Teugbyeolsi 06351
Korea, Republic ofActive - Recruiting
Seoul National University Hospital /ID# 242407
Seoul, Seoul Teugbyeolsi 03080
Korea, Republic ofActive - Recruiting
The Catholic University of Korea, Seoul St. Marys Hospital /ID# 242406
Seoul, Seoul Teugbyeolsi 06591
Korea, Republic ofActive - Recruiting
Ulsan University Hospital /ID# 242956
Ulsan, Ulsan Gwang Yeogsi 44033
Korea, Republic ofActive - Recruiting
Medisch Centrum Leeuwarden /ID# 245501
Leeuwarden, Friesland 8934 AD
NetherlandsActive - Recruiting
Jeroen Bosch Ziekenhuis, locatie 's-Hertogenbosch /ID# 265204
's-Hertogenbosch, Noord-Brabant 5223 GZ
NetherlandsActive - Recruiting
OLVG - Locatie Oost /ID# 263355
Amsterdam, Noord-Holland 1091 AC
NetherlandsActive - Recruiting
St. Antonius Ziekenhuis /ID# 245197
Nieuwegein, Utrecht 3435 CM
NetherlandsActive - Recruiting
Albert Schweitzer Ziekenhuis, locatie Dordwijk /ID# 263361
Dordrecht, Zuid-Holland 3318 AT
NetherlandsActive - Recruiting
North Shore Hospital /ID# 266060
Auckland, 0622
New ZealandActive - Recruiting
Wellington Hospital /ID# 265966
Wellington, 6021
New ZealandActive - Recruiting
Pratia MCM Krakow /ID# 262882
Krakow, Malopolskie 30-727
PolandActive - Recruiting
Narodowy Instytut Onkologii im. Marii Sklodowskiej-Curie Panstwowy Instytut Bada /ID# 263314
Warsaw, Mazowieckie 02-781
PolandActive - Recruiting
Swietokrzyskie Centrum Onkologii Samodzielny Publiczny Zaklad Opieki Zdrowotnej /ID# 242436
Kielce, Swietokrzyskie 25-734
PolandActive - Recruiting
Aidport sp z o.o. /ID# 262766
Poznan, Wielkopolskie 60-175
PolandActive - Recruiting
Hospital da Luz /ID# 262965
Lisbon, Lisboa 1500-650
PortugalActive - Recruiting
Instituto Portugues de Oncologia do Porto Francisco Gentil, EPE /ID# 262961
Porto, 4200-072
PortugalActive - Recruiting
Unidade Local de Saude de Sao Joao, EPE /ID# 262962
Porto, 4202-451
PortugalActive - Recruiting
Fundeni Clinical Institute /ID# 266734
Bucharest, Bucuresti 022328
RomaniaActive - Recruiting
Institutul Oncologic Prof Dr I Chiricuta /ID# 243753
Cluj Napoca, Cluj 400015
RomaniaActive - Recruiting
Institutul Regional de Oncologie /ID# 244367
Jassi, Iasi 700483
RomaniaActive - Recruiting
Spitalul Clinic Coltea /ID# 243694
Bucharest, 030171
RomaniaActive - Recruiting
Clinical Hospital Center - Bežanijska Kosa /ID# 263053
Belgrade, Beograd 11080
SerbiaActive - Recruiting
Clinical Hospital Center Zvezdara /ID# 263059
Belgrade, Beograd 11000
SerbiaActive - Recruiting
Institute for Oncology and Radiology of Serbia /ID# 263055
Belgrade, Beograd 11000
SerbiaActive - Recruiting
University Clinical Center Serbia /ID# 263057
Belgrade, Beograd 11000
SerbiaActive - Recruiting
University Clinical Center Nis /ID# 263701
Niš, Nisavski Okrug 18300
SerbiaActive - Recruiting
Institute for Oncology of Vojvodina /ID# 263052
Sremska Kamenica, Vojvodina 21208
SerbiaActive - Recruiting
University Clinical Center Vojvodina /ID# 264138
Novi Sad, 21000
SerbiaActive - Recruiting
National Cancer Centre Singapore /ID# 267015
Singapore, Central Singapore 169611
SingaporeActive - Recruiting
National University Hospital /ID# 264016
Singapore, 119074
SingaporeActive - Recruiting
Alberts Cellular Therapy /ID# 262720
Pretoria, Gauteng 0044
South AfricaActive - Recruiting
Haemalife Inc. /ID# 262719
Kuilsrivier, Western Cape 7580
South AfricaActive - Recruiting
National Taiwan University Hospital /ID# 243300
Taipei City, Taipei 100
TaiwanActive - Recruiting
China Medical University Hospital /ID# 242931
Taichung, 40447
TaiwanActive - Recruiting
Taichung Veterans General Hospital /ID# 242937
Taichung, 40705
TaiwanActive - Recruiting
National Cheng Kung University Hospital /ID# 243301
Tainan, 704
TaiwanActive - Recruiting
Adnan Menderes University /ID# 242418
Aydin, 09100
TurkeyActive - Recruiting
Trakya University Medical Facu /ID# 242419
Edirne, Istanbul, 22030
TurkeyActive - Recruiting
Ondokuz mayis University Facul /ID# 242412
Samsun, 55200
TurkeyActive - Recruiting
Nottingham City Hospital /ID# 265129
Nottingham, Nottinghamshire NG5 1PB
United KingdomActive - Recruiting
Valkyrie Clinical Trials /ID# 269935
Los Angeles, California 90067
United StatesActive - Recruiting
Lutheran Medical Center- Cancer Centers of Colorado /ID# 265823
Golden, Colorado 80401
United StatesActive - Recruiting
Northwest Cancer Center - Dyer Clinic /ID# 269787
Dyer, Indiana 46311
United StatesActive - Recruiting
Cancer Center of Kansas - Wichita /ID# 270117
Wichita, Kansas 67214
United StatesActive - Recruiting
Gulfport Memorial Hospital /ID# 268104
Gulfport, Mississippi 39501
United StatesActive - Recruiting
New York Medical College /ID# 265799
Valhalla, New York 10595
United StatesActive - Recruiting
Thompson Cancer Survival Ctr /ID# 242149
Knoxville, Tennessee 37916
United StatesActive - Recruiting
Community Cancer Trials Of Utah /ID# 271715
Ogden, Utah 84405
United StatesActive - Recruiting
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